Assay Detail
Binding
CHEMBL1245083
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Inhibition of Hepatitis C virus genotype 1a NS3/4A protease activity
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Hepatitis C virus subtype 1a |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
MK-7009, a potent and selective inhibitor of hepatitis C virus NS3/4A protease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 8.45 | 10.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4525964 | VANIPREVIR | 3.0 | 1 | 10.15 |
| CHEMBL297884 | CILUPREVIR | 2.0 | 1 | 9.09 |
| CHEMBL218394 | BOCEPREVIR | 4.0 | 1 | 7.68 |
| CHEMBL231813 | TELAPREVIR | 4.0 | 1 | 6.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4525964 | VANIPREVIR | Ki | = | 0.07 | nM | 10.15 |
| CHEMBL297884 | CILUPREVIR | Ki | = | 0.81 | nM | 9.09 |
| CHEMBL218394 | BOCEPREVIR | Ki | = | 21.0 | nM | 7.68 |
| CHEMBL231813 | TELAPREVIR | Ki | = | 130.0 | nM | 6.89 |