Assay Detail
Binding
CHEMBL1246065
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human GST-CDK1/cyclin B1 expressed in baculovirus using [gamma-33P]ATP after 45 mins by liquid scintillation counting
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
Cyclin-dependent kinase 1/cyclin B1 (CHEMBL1907602) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
Discovery of novel CDK1 inhibitors by combining pharmacophore modeling, QSAR analysis and in silico screening followed by in vitro bioassay.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.33 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL428690 | ALVOCIDIB | 3.0 | 1 | 7.52 |
| CHEMBL296586 | KENPAULLONE | — | 1 | 6.40 |
| CHEMBL1242973 | BUTYROLACTONE I | — | 1 | 6.22 |
| CHEMBL280074 | OLOMOUCINE | — | 1 | 5.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL428690 | ALVOCIDIB | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL296586 | KENPAULLONE | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL1242973 | BUTYROLACTONE I | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL280074 | OLOMOUCINE | IC50 | = | 7000.0 | nM | 5.16 |