Assay Detail
Binding
CHEMBL1246371
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Inhibition of hedgehog receptor mediated Gli transcription
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Modulators of the hedgehog signaling pathway.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 6.41 | 6.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL254129 | CYCLOPAMINE | — | 1 | 6.52 |
| CHEMBL186779 | JERVINE | — | 1 | 6.30 |
| CHEMBL1241233 | CYCLOPOSINE | — | 1 | - |
| CHEMBL464724 | VERATRAMINE | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL254129 | CYCLOPAMINE | EC50 | = | 300.0 | nM | 6.52 |
| CHEMBL186779 | JERVINE | EC50 | = | 500.0 | nM | 6.30 |
| CHEMBL1241233 | CYCLOPOSINE | EC50 | > | 700.0 | nM | - |
| CHEMBL464724 | VERATRAMINE | EC50 | - | — | - |