Assay Detail
Binding
CHEMBL1246374
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Inhibition of human recombinant MAOA expressed in baculovirus infected insect BTI-TN-5B1-4 cells assessed as production of hydrogen peroxide from p-tyramine by amplex red assay
36
Total Activities
36
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | BTI-TN-5B1-4 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis, stereochemical separation, and biological evaluation of selective inhibitors of human MAO-B: 1-(4-arylthiazol-2-yl)-2-(3-methylcyclohexylidene)hydrazines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 36 | 4.72 | 5.56 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL399353 | — | — | 1 | 5.56 |
| CHEMBL1242938 | — | — | 1 | 5.45 |
| CHEMBL1243125 | — | — | 1 | 5.37 |
| CHEMBL1242992 | — | — | 1 | 5.32 |
| CHEMBL1242964 | — | — | 1 | 5.31 |
| CHEMBL1243400 | — | — | 1 | 5.26 |
| CHEMBL495714 | — | — | 1 | 5.24 |
| CHEMBL92401 | IPRONIAZID | 2.0 | 1 | 5.18 |
| CHEMBL1242991 | — | — | 1 | 5.17 |
| CHEMBL1243401 | — | — | 1 | 5.14 |
| CHEMBL1243089 | — | — | 1 | 5.00 |
| CHEMBL1243182 | — | — | 1 | 4.77 |
| CHEMBL1243180 | — | — | 1 | 4.69 |
| CHEMBL1243181 | — | — | 1 | 4.66 |
| CHEMBL1243213 | — | — | 1 | 4.64 |
| CHEMBL1243212 | — | — | 1 | 4.64 |
| CHEMBL1243399 | — | — | 1 | 4.51 |
| CHEMBL1242936 | — | — | 1 | 4.45 |
| CHEMBL1243214 | — | — | 1 | 4.43 |
| CHEMBL1241294 | — | — | 1 | 4.42 |
| CHEMBL1240558 | — | — | 1 | 4.42 |
| CHEMBL1243088 | — | — | 1 | 4.41 |
| CHEMBL1241295 | — | — | 1 | 4.41 |
| CHEMBL326294 | ISATIN | — | 1 | 4.40 |
| CHEMBL1243245 | — | — | 1 | 4.39 |
| CHEMBL1243058 | — | — | 1 | 4.39 |
| CHEMBL375539 | — | — | 1 | 4.38 |
| CHEMBL1243371 | — | — | 1 | 4.37 |
| CHEMBL1243059 | — | — | 1 | 4.37 |
| CHEMBL1242937 | — | — | 1 | 4.36 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL399353 | — | IC50 | = | 2760.0 | nM | 5.56 |
| CHEMBL1242938 | — | IC50 | = | 3530.0 | nM | 5.45 |
| CHEMBL1243125 | — | IC50 | = | 4260.0 | nM | 5.37 |
| CHEMBL1242992 | — | IC50 | = | 4810.0 | nM | 5.32 |
| CHEMBL1242964 | — | IC50 | = | 4940.0 | nM | 5.31 |
| CHEMBL1243400 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL495714 | — | IC50 | = | 5770.0 | nM | 5.24 |
| CHEMBL92401 | IPRONIAZID | IC50 | = | 6560.0 | nM | 5.18 |
| CHEMBL1242991 | — | IC50 | = | 6830.0 | nM | 5.17 |
| CHEMBL1243401 | — | IC50 | = | 7220.0 | nM | 5.14 |
| CHEMBL1243089 | — | IC50 | = | 10090.0 | nM | 5.00 |
| CHEMBL1243182 | — | IC50 | = | 17140.0 | nM | 4.77 |
| CHEMBL1243180 | — | IC50 | = | 20570.0 | nM | 4.69 |
| CHEMBL1243181 | — | IC50 | = | 21900.0 | nM | 4.66 |
| CHEMBL1243212 | — | IC50 | = | 23120.0 | nM | 4.64 |
| CHEMBL1243213 | — | IC50 | = | 22760.0 | nM | 4.64 |
| CHEMBL1243399 | — | IC50 | = | 31030.0 | nM | 4.51 |
| CHEMBL1242936 | — | IC50 | = | 35220.0 | nM | 4.45 |
| CHEMBL1243214 | — | IC50 | = | 37520.0 | nM | 4.43 |
| CHEMBL1240558 | — | IC50 | = | 37950.0 | nM | 4.42 |
| CHEMBL1241294 | — | IC50 | = | 37840.0 | nM | 4.42 |
| CHEMBL1243088 | — | IC50 | = | 38840.0 | nM | 4.41 |
| CHEMBL1241295 | — | IC50 | = | 38610.0 | nM | 4.41 |
| CHEMBL326294 | ISATIN | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL1243245 | — | IC50 | = | 40320.0 | nM | 4.39 |
| CHEMBL1243058 | — | IC50 | = | 40570.0 | nM | 4.39 |
| CHEMBL375539 | — | IC50 | = | 41230.0 | nM | 4.38 |
| CHEMBL1243371 | — | IC50 | = | 42310.0 | nM | 4.37 |
| CHEMBL1243059 | — | IC50 | = | 42660.0 | nM | 4.37 |
| CHEMBL1242937 | — | IC50 | = | 43550.0 | nM | 4.36 |
| CHEMBL1243057 | — | IC50 | = | 43780.0 | nM | 4.36 |
| CHEMBL1243026 | — | IC50 | = | 43950.0 | nM | 4.36 |
| CHEMBL1242965 | — | IC50 | = | 44700.0 | nM | 4.35 |
| CHEMBL972 | SELEGILINE | IC50 | = | 67250.0 | nM | 4.17 |
| CHEMBL86304 | MOCLOBEMIDE | IC50 | = | 361380.0 | nM | - |
| CHEMBL8706 | CLORGILINE | IC50 | = | 4.46 | nM | - |