Assay Detail
Binding
CHEMBL1246375
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Inhibition of human recombinant MAOB expressed in baculovirus infected insect BTI-TN-5B1-4 cells assessed as production of hydrogen peroxide from p-tyramine by amplex red assay
42
Total Activities
42
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | BTI-TN-5B1-4 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis, stereochemical separation, and biological evaluation of selective inhibitors of human MAO-B: 1-(4-arylthiazol-2-yl)-2-(3-methylcyclohexylidene)hydrazines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 42 | 6.41 | 8.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1243026 | — | — | 1 | 8.05 |
| CHEMBL1240558 | — | — | 1 | 7.85 |
| CHEMBL1243371 | — | — | 1 | 7.80 |
| CHEMBL1243088 | — | — | 1 | 7.75 |
| CHEMBL1242938 | — | — | 1 | 7.70 |
| CHEMBL972 | SELEGILINE | 4.0 | 1 | 7.70 |
| CHEMBL1243399 | — | — | 1 | 7.58 |
| CHEMBL1242991 | — | — | 1 | 7.52 |
| CHEMBL1243400 | — | — | 1 | 7.50 |
| CHEMBL1243025 | — | — | 1 | 7.50 |
| CHEMBL1242992 | — | — | 1 | 7.44 |
| CHEMBL1242964 | — | — | 1 | 7.40 |
| CHEMBL1243059 | — | — | 1 | 7.25 |
| CHEMBL1243401 | — | — | 1 | 7.20 |
| CHEMBL1243151 | — | — | 1 | 7.07 |
| CHEMBL1243180 | — | — | 1 | 6.92 |
| CHEMBL246813 | — | — | 1 | 6.85 |
| CHEMBL1243124 | — | — | 1 | 6.82 |
| CHEMBL1242937 | — | — | 1 | 6.70 |
| CHEMBL1243152 | — | — | 1 | 6.68 |
| CHEMBL1243181 | — | — | 1 | 6.64 |
| CHEMBL1243089 | — | — | 1 | 6.58 |
| CHEMBL1243150 | — | — | 1 | 6.39 |
| CHEMBL1243214 | — | — | 1 | 6.39 |
| CHEMBL1243182 | — | — | 1 | 6.38 |
| CHEMBL375539 | — | — | 1 | 6.15 |
| CHEMBL1241295 | — | — | 1 | 6.09 |
| CHEMBL1243245 | — | — | 1 | 6.09 |
| CHEMBL1241294 | — | — | 1 | 5.65 |
| CHEMBL399353 | — | — | 1 | 5.62 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1243026 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL1240558 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL1243371 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL1243088 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL1242938 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL972 | SELEGILINE | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL1243399 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL1242991 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL1243400 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL1243025 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL1242992 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL1242964 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL1243059 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL1243401 | — | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL1243151 | — | IC50 | = | 86.0 | nM | 7.07 |
| CHEMBL1243180 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL246813 | — | IC50 | = | 142.0 | nM | 6.85 |
| CHEMBL1243124 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL1242937 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL1243152 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL1243181 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL1243089 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL1243214 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL1243150 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL1243182 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL375539 | — | IC50 | = | 710.0 | nM | 6.15 |
| CHEMBL1241295 | — | IC50 | = | 810.0 | nM | 6.09 |
| CHEMBL1243245 | — | IC50 | = | 810.0 | nM | 6.09 |
| CHEMBL1241294 | — | IC50 | = | 2230.0 | nM | 5.65 |
| CHEMBL399353 | — | IC50 | = | 2370.0 | nM | 5.62 |
| CHEMBL1243090 | — | IC50 | = | 2860.0 | nM | 5.54 |
| CHEMBL1243125 | — | IC50 | = | 3120.0 | nM | 5.51 |
| CHEMBL1243058 | — | IC50 | = | 3680.0 | nM | 5.43 |
| CHEMBL495714 | — | IC50 | = | 4510.0 | nM | 5.35 |
| CHEMBL92401 | IPRONIAZID | IC50 | = | 7540.0 | nM | 5.12 |
| CHEMBL1243213 | — | IC50 | = | 9550.0 | nM | 5.02 |
| CHEMBL1243057 | — | IC50 | = | 9650.0 | nM | 5.01 |
| CHEMBL1242936 | — | IC50 | = | 13120.0 | nM | 4.88 |
| CHEMBL326294 | ISATIN | IC50 | = | 18750.0 | nM | 4.73 |
| CHEMBL1243212 | — | IC50 | = | 21900.0 | nM | 4.66 |
| CHEMBL1242965 | — | IC50 | = | 26810.0 | nM | 4.57 |
| CHEMBL8706 | CLORGILINE | IC50 | = | 61350.0 | nM | 4.21 |