Assay Detail
Binding
CHEMBL1246629
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement [3H]prazosin of human recombinant alpha1A adrenergic receptor expressed in CHO cells by rapid filtration technique
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
1,3-Dioxolane-based ligands incorporating a lactam or imide moiety: structure-affinity/activity relationship at alpha1-adrenoceptor subtypes and at 5-HT1A receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 15 | 8.18 | 9.58 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1242352 | — | — | 1 | 9.58 |
| CHEMBL1242632 | — | — | 1 | 9.20 |
| CHEMBL1242541 | — | — | 1 | 9.06 |
| CHEMBL1242444 | — | — | 1 | 8.86 |
| CHEMBL1242912 | — | — | 1 | 8.69 |
| CHEMBL1242724 | — | — | 1 | 8.54 |
| CHEMBL1242818 | — | — | 1 | 8.18 |
| CHEMBL1241557 | — | — | 1 | 8.00 |
| CHEMBL1242542 | — | — | 1 | 7.94 |
| CHEMBL1242445 | — | — | 1 | 7.90 |
| CHEMBL31354 | WAY-100,635 | — | 1 | 7.73 |
| CHEMBL1242819 | — | — | 1 | 7.67 |
| CHEMBL1242633 | — | — | 1 | 7.57 |
| CHEMBL1242725 | — | — | 1 | 7.39 |
| CHEMBL13647 | BMY-7378 | — | 1 | 6.42 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1242352 | — | Ki | = | 0.263 | nM | 9.58 |
| CHEMBL1242632 | — | Ki | = | 0.631 | nM | 9.20 |
| CHEMBL1242541 | — | Ki | = | 0.871 | nM | 9.06 |
| CHEMBL1242444 | — | Ki | = | 1.38 | nM | 8.86 |
| CHEMBL1242912 | — | Ki | = | 2.042 | nM | 8.69 |
| CHEMBL1242724 | — | Ki | = | 2.884 | nM | 8.54 |
| CHEMBL1242818 | — | Ki | = | 6.607 | nM | 8.18 |
| CHEMBL1241557 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL1242542 | — | Ki | = | 11.48 | nM | 7.94 |
| CHEMBL1242445 | — | Ki | = | 12.59 | nM | 7.90 |
| CHEMBL31354 | WAY-100,635 | Ki | = | 18.62 | nM | 7.73 |
| CHEMBL1242819 | — | Ki | = | 21.38 | nM | 7.67 |
| CHEMBL1242633 | — | Ki | = | 26.92 | nM | 7.57 |
| CHEMBL1242725 | — | Ki | = | 40.74 | nM | 7.39 |
| CHEMBL13647 | BMY-7378 | Ki | = | 380.19 | nM | 6.42 |