Assay Detail
Binding
CHEMBL1246631
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement [3H]prazosin of human recombinant Alpha-1D adrenergic receptor expressed in CHO cells by rapid filtration technique
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
1,3-Dioxolane-based ligands incorporating a lactam or imide moiety: structure-affinity/activity relationship at alpha1-adrenoceptor subtypes and at 5-HT1A receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 15 | 8.27 | 9.09 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1242352 | — | — | 1 | 9.09 |
| CHEMBL13647 | BMY-7378 | — | 1 | 8.89 |
| CHEMBL1241557 | — | — | 1 | 8.86 |
| CHEMBL1242542 | — | — | 1 | 8.83 |
| CHEMBL1242633 | — | — | 1 | 8.60 |
| CHEMBL1242632 | — | — | 1 | 8.39 |
| CHEMBL31354 | WAY-100,635 | — | 1 | 8.34 |
| CHEMBL1242912 | — | — | 1 | 8.32 |
| CHEMBL1242445 | — | — | 1 | 8.28 |
| CHEMBL1242819 | — | — | 1 | 8.07 |
| CHEMBL1242444 | — | — | 1 | 7.87 |
| CHEMBL1242541 | — | — | 1 | 7.85 |
| CHEMBL1242725 | — | — | 1 | 7.79 |
| CHEMBL1242818 | — | — | 1 | 7.49 |
| CHEMBL1242724 | — | — | 1 | 7.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1242352 | — | Ki | = | 0.8128 | nM | 9.09 |
| CHEMBL13647 | BMY-7378 | Ki | = | 1.288 | nM | 8.89 |
| CHEMBL1241557 | — | Ki | = | 1.38 | nM | 8.86 |
| CHEMBL1242542 | — | Ki | = | 1.479 | nM | 8.83 |
| CHEMBL1242633 | — | Ki | = | 2.512 | nM | 8.60 |
| CHEMBL1242632 | — | Ki | = | 4.074 | nM | 8.39 |
| CHEMBL31354 | WAY-100,635 | Ki | = | 4.571 | nM | 8.34 |
| CHEMBL1242912 | — | Ki | = | 4.786 | nM | 8.32 |
| CHEMBL1242445 | — | Ki | = | 5.248 | nM | 8.28 |
| CHEMBL1242819 | — | Ki | = | 8.511 | nM | 8.07 |
| CHEMBL1242444 | — | Ki | = | 13.49 | nM | 7.87 |
| CHEMBL1242541 | — | Ki | = | 14.13 | nM | 7.85 |
| CHEMBL1242725 | — | Ki | = | 16.22 | nM | 7.79 |
| CHEMBL1242818 | — | Ki | = | 32.36 | nM | 7.49 |
| CHEMBL1242724 | — | Ki | = | 39.81 | nM | 7.40 |