Assay Detail
Binding
CHEMBL1246708
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Inhibition of PGPH catalytic activity of 20S proteasome beta2 in human LCL cells after 12 hrs by in vivo assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | LCL |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Alpha,beta-unsaturated N-acylpyrrole peptidyl derivatives: new proteasome inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.97 | 7.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1240771 | — | — | 1 | 7.24 |
| CHEMBL1240769 | — | — | 1 | 6.94 |
| CHEMBL1243081 | — | — | 1 | 6.87 |
| CHEMBL1240770 | — | — | 1 | 6.83 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1240771 | — | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL1240769 | — | IC50 | = | 116.0 | nM | 6.94 |
| CHEMBL1243081 | — | IC50 | = | 135.0 | nM | 6.87 |
| CHEMBL1240770 | — | IC50 | = | 147.0 | nM | 6.83 |