Assay Detail
Binding
CHEMBL1246851
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Inhibition of sheep COX2 by spectrophotometry
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Ovis aries |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis, anti-inflammatory activity, and in vitro antitumor effect of a novel class of cyclooxygenase inhibitors: 4-(aryloyl)phenyl methyl sulfones.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 5.24 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL118 | CELECOXIB | 4.0 | 1 | 7.00 |
| CHEMBL1240964 | — | — | 1 | 6.52 |
| CHEMBL122 | ROFECOXIB | 4.0 | 1 | 6.11 |
| CHEMBL1240922 | — | — | 1 | 6.00 |
| CHEMBL1240924 | — | — | 1 | 5.89 |
| CHEMBL175 | DEXIBUPROFEN | 4.0 | 1 | 5.82 |
| CHEMBL1240925 | — | — | 1 | 5.70 |
| CHEMBL1240537 | — | — | 1 | 5.39 |
| CHEMBL1240923 | — | — | 1 | 5.11 |
| CHEMBL1240963 | — | — | 1 | 5.07 |
| CHEMBL1243098 | — | — | 1 | 5.03 |
| CHEMBL1240889 | — | — | 1 | 4.82 |
| CHEMBL1243100 | — | — | 1 | 4.73 |
| CHEMBL1240887 | — | — | 1 | 4.72 |
| CHEMBL1243067 | — | — | 1 | 4.71 |
| CHEMBL1240888 | — | — | 1 | 4.64 |
| CHEMBL1243099 | — | — | 1 | 4.58 |
| CHEMBL1243065 | — | — | 1 | 4.43 |
| CHEMBL1243066 | — | — | 1 | 4.36 |
| CHEMBL7162 | NS-398 | — | 1 | 4.13 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL118 | CELECOXIB | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL1240964 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL122 | ROFECOXIB | IC50 | = | 780.0 | nM | 6.11 |
| CHEMBL1240922 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL1240924 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL175 | DEXIBUPROFEN | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL1240925 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL1240537 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL1240923 | — | IC50 | = | 7700.0 | nM | 5.11 |
| CHEMBL1240963 | — | IC50 | = | 8500.0 | nM | 5.07 |
| CHEMBL1243098 | — | IC50 | = | 9400.0 | nM | 5.03 |
| CHEMBL1240889 | — | IC50 | = | 15200.0 | nM | 4.82 |
| CHEMBL1243100 | — | IC50 | = | 18800.0 | nM | 4.73 |
| CHEMBL1240887 | — | IC50 | = | 19200.0 | nM | 4.72 |
| CHEMBL1243067 | — | IC50 | = | 19700.0 | nM | 4.71 |
| CHEMBL1240888 | — | IC50 | = | 23100.0 | nM | 4.64 |
| CHEMBL1243099 | — | IC50 | = | 26500.0 | nM | 4.58 |
| CHEMBL1243065 | — | IC50 | = | 36800.0 | nM | 4.43 |
| CHEMBL1243066 | — | IC50 | = | 43300.0 | nM | 4.36 |
| CHEMBL7162 | NS-398 | IC50 | = | 73200.0 | nM | 4.13 |