Assay Detail
Functional
CHEMBL1246879
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Antimicrobial activity against Plasmodium falciparum harboring mdr1 N86Y/D1246Y/Y184F mutant gene by ELISA
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
In vitro sensitivities of Plasmodium falciparum to different antimalarial drugs in Uganda.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 8.47 | 9.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL38827 | LUMEFANTRINE | 4.0 | 1 | 9.72 |
| CHEMBL303933 | PIPERAQUINE | 3.0 | 1 | 8.80 |
| CHEMBL1235 | DESETHYL AMODIAQUINE | — | 1 | 8.20 |
| CHEMBL170 | QUININE | 4.0 | 1 | 7.81 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 7.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL38827 | LUMEFANTRINE | IC50 | = | 0.19 | nM | 9.72 |
| CHEMBL303933 | PIPERAQUINE | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL1235 | DESETHYL AMODIAQUINE | IC50 | = | 6.3 | nM | 8.20 |
| CHEMBL170 | QUININE | IC50 | = | 15.4 | nM | 7.81 |
| CHEMBL76 | CHLOROQUINE | IC50 | = | 15.7 | nM | 7.80 |