Assay Detail
Functional
CHEMBL1247283
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Cytotoxicity against human A549 cells after 72 hrs by MTT assay
10
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A549 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis of 5-[alkoxy-(4-nitro-phenyl)-methyl]-uridines and study of their cytotoxic activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 4.55 | 5.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL727 | THIOGUANINE | 4.0 | 1 | 5.55 |
| CHEMBL1241838 | — | — | 2 | 4.64 |
| CHEMBL1241837 | — | — | 2 | 4.41 |
| CHEMBL1241748 | — | — | 2 | 4.40 |
| CHEMBL1568 | FLUDARABINE | 3.0 | 1 | 4.32 |
| CHEMBL1241747 | — | — | 2 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL727 | THIOGUANINE | IC50 | = | 2820.0 | nM | 5.55 |
| CHEMBL1241838 | — | IC50 | = | 23100.0 | nM | 4.64 |
| CHEMBL1241838 | — | IC50 | = | 29100.0 | nM | 4.54 |
| CHEMBL1241837 | — | IC50 | = | 38700.0 | nM | 4.41 |
| CHEMBL1241748 | — | IC50 | = | 39800.0 | nM | 4.40 |
| CHEMBL1241837 | — | IC50 | = | 39700.0 | nM | 4.40 |
| CHEMBL1568 | FLUDARABINE | IC50 | = | 47440.0 | nM | 4.32 |
| CHEMBL1241748 | — | IC50 | = | 69900.0 | nM | 4.16 |
| CHEMBL1241747 | — | IC50 | = | 121300.0 | nM | - |
| CHEMBL1241747 | — | IC50 | = | 156000.0 | nM | - |