Assay Detail
Binding
CHEMBL1247352
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Binding affinity to human histamine H4 receptor
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Investigation of the histamine H3 receptor binding site. Design and synthesis of hybrid agonists with a lipophilic side chain.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 6.54 | 7.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1243367 | — | — | 1 | 7.77 |
| CHEMBL1243395 | — | — | 1 | 6.51 |
| CHEMBL1243366 | — | — | 1 | 6.44 |
| CHEMBL1243335 | — | — | 1 | 6.08 |
| CHEMBL1243394 | — | — | 1 | 5.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1243367 | — | Ki | = | 17.0 | nM | 7.77 |
| CHEMBL1243395 | — | Ki | = | 310.0 | nM | 6.51 |
| CHEMBL1243366 | — | Ki | = | 360.0 | nM | 6.44 |
| CHEMBL1243335 | — | Ki | = | 840.0 | nM | 6.08 |
| CHEMBL1243394 | — | Ki | = | 1300.0 | nM | 5.89 |