Assay Detail
Functional
CHEMBL1248124
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Antiviral activity against ganciclovir-resistant human cytomegalovirus isolate 1947R infected in NHDF assessed as inhibition of virus-induced cytopathic effect after 6 to 7 days by giemsa staining
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human betaherpesvirus 5 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
In vitro and in vivo activities of the novel anticytomegalovirus compound AIC246.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 2 | 6.73 | 8.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1241951 | LETERMOVIR | 4.0 | 1 | 8.64 |
| CHEMBL182 | GANCICLOVIR | 4.0 | 1 | 4.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1241951 | LETERMOVIR | EC50 | = | 2.3 | nM | 8.64 |
| CHEMBL182 | GANCICLOVIR | EC50 | = | 15000.0 | nM | 4.82 |