Assay Detail
Functional
CHEMBL1248459
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human Caco-2 cells after 3 days by [3H]thymidine incorporation assay
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Caco-2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
In vitro and in vivo studies on stilbene analogs as potential treatment agents for colon cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 27 | 5.11 | 7.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL311636 | 8Z-3,4',5-TRIMETHOXYSTILBENE | — | 1 | 7.10 |
| CHEMBL1241312 | — | — | 1 | 6.23 |
| CHEMBL116776 | — | — | 1 | 5.58 |
| CHEMBL1242274 | — | — | 1 | 5.53 |
| CHEMBL1241285 | — | — | 1 | 5.15 |
| CHEMBL296411 | TRISMETHOXYRESVERATROL | — | 1 | 4.92 |
| CHEMBL83527 | PTEROSTILBENE | 2.0 | 1 | 4.84 |
| CHEMBL1242096 | — | — | 1 | 4.83 |
| CHEMBL207367 | — | — | 1 | 4.73 |
| CHEMBL498917 | — | — | 1 | 4.72 |
| CHEMBL259003 | — | — | 1 | 4.71 |
| CHEMBL324290 | — | — | 1 | 4.71 |
| CHEMBL210300 | — | — | 1 | 4.64 |
| CHEMBL165 | RESVERATROL | 3.0 | 1 | 4.61 |
| CHEMBL440409 | — | — | 1 | 4.37 |
| CHEMBL1242273 | — | — | 1 | - |
| CHEMBL65214 | — | — | 1 | - |
| CHEMBL369262 | — | — | 1 | - |
| CHEMBL179374 | — | — | 1 | - |
| CHEMBL1241313 | — | — | 1 | - |
| CHEMBL1172974 | — | — | 1 | - |
| CHEMBL1242184 | — | — | 1 | - |
| CHEMBL313687 | — | — | 1 | - |
| CHEMBL291501 | RESVERATROL 4'-METHYL ETHER | — | 1 | - |
| CHEMBL488414 | — | — | 1 | - |
| CHEMBL1242183 | — | — | 1 | - |
| CHEMBL1242097 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL311636 | 8Z-3,4',5-TRIMETHOXYSTILBENE | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL1241312 | — | IC50 | = | 590.0 | nM | 6.23 |
| CHEMBL116776 | — | IC50 | = | 2610.0 | nM | 5.58 |
| CHEMBL1242274 | — | IC50 | = | 2950.0 | nM | 5.53 |
| CHEMBL1241285 | — | IC50 | = | 7100.0 | nM | 5.15 |
| CHEMBL296411 | TRISMETHOXYRESVERATROL | IC50 | = | 11950.0 | nM | 4.92 |
| CHEMBL83527 | PTEROSTILBENE | IC50 | = | 14460.0 | nM | 4.84 |
| CHEMBL1242096 | — | IC50 | = | 14710.0 | nM | 4.83 |
| CHEMBL207367 | — | IC50 | = | 18430.0 | nM | 4.73 |
| CHEMBL498917 | — | IC50 | = | 19210.0 | nM | 4.72 |
| CHEMBL259003 | — | IC50 | = | 19590.0 | nM | 4.71 |
| CHEMBL324290 | — | IC50 | = | 19570.0 | nM | 4.71 |
| CHEMBL210300 | — | IC50 | = | 22870.0 | nM | 4.64 |
| CHEMBL165 | RESVERATROL | IC50 | = | 24350.0 | nM | 4.61 |
| CHEMBL440409 | — | IC50 | = | 42640.0 | nM | 4.37 |
| CHEMBL1242273 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL65214 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL369262 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL179374 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1241313 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1172974 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1242184 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL313687 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL291501 | RESVERATROL 4'-METHYL ETHER | IC50 | > | 30000.0 | nM | - |
| CHEMBL488414 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL1242183 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL1242097 | — | IC50 | > | 30000.0 | nM | - |