Assay Detail
Functional
CHEMBL1248666
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Antimalarial activity against NITD678-resistant Plasmodium falciparum Dd2 Clone1 bearing P-type ATPase4 G223R mutations after 72 hrs by SYBR green based fluorescence assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Spiroindolones, a potent compound class for the treatment of malaria.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 7.63 | 8.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1082723 | CIPARGAMIN | 2.0 | 1 | 8.55 |
| CHEMBL1083769 | — | — | 1 | 6.71 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1082723 | CIPARGAMIN | IC50 | = | 2.8 | nM | 8.55 |
| CHEMBL1083769 | — | IC50 | = | 192.9 | nM | 6.71 |