Assay Detail

CHEMBL1248667

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional

Antimalarial activity against NITD678-resistant Plasmodium falciparum Dd2 Clone2 bearing P-type ATPase4 A184S and P990Y mutations after 72 hrs by SYBR green based fluorescence assay

ChEMBL ↗

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Target

Plasmodium falciparum (CHEMBL364) ↗

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Primary target Plasmodium falciparum

CHEMBL364

Anchored from Assay target.

Protein identity Plasmodium falciparum

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Plasmodium falciparum
Confidence	1 — Organism
Curated By	Autocuration

Target

Plasmodium falciparum (CHEMBL364) ↗

Type	ORGANISM
Organism	Plasmodium falciparum

Publication

Spiroindolones, a potent compound class for the treatment of malaria.

Rottmann M, McNamara C, Yeung BK, Lee MC, Zou B, Russell B, Seitz P, Plouffe DM, Dharia NV, Tan J, Cohen SB, Spencer KR, González-Páez GE, Lakshminarayana SB, Goh A, Suwanarusk R, Jegla T, Schmitt EK, Beck HP, Brun R, Nosten F, Renia L, Dartois V, Keller TH, Fidock DA, Winzeler EA, Diagana TT.
Science (2010) 329 : 1175 -1180
PubMed 20813948 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	2	7.67	8.55

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL1082723	CIPARGAMIN	2.0	1	8.55
CHEMBL1083769	—	—	1	6.79

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL1082723	CIPARGAMIN	IC50	=	2.8	nM	8.55
CHEMBL1083769	—	IC50	=	162.0	nM	6.79