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Assay Detail

CHEMBL1249409

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Functional
Antiproliferative activity against human U2OS cells expressing constitutively active Stat3 mutant after 48 hrs by CMV-GFP reporter assay method
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type U2OS
Confidence 1 — Organism
Curated By Autocuration

Target

U2OS (CHEMBL615023)
Type CELL-LINE
Organism Homo sapiens

Publication

A functional genomics approach to the mode of action of apratoxin A.
Luesch H, Chanda SK, Raya RM, DeJesus PD, Orth AP, Walker JR, Izpisúa Belmonte JC, Schultz PG.
Nat Chem Biol (2006) 2 : 158 -167
PubMed 16474387 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 1 7.30 7.30

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL501696 APRATOXIN A 1 7.30

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL501696 APRATOXIN A IC50 = 50.0 nM 7.30