Assay Detail
Functional
CHEMBL1249903
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human OPM2 cells after 72 hrs by alamar blue assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | OPM-2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Seliciclib (CYC202, R-Roscovitine) induces cell death in multiple myeloma cells by inhibition of RNA polymerase II-dependent transcription and down-regulation of Mcl-1.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 4.63 | 4.73 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL14762 | SELICICLIB | 2.0 | 1 | 4.73 |
| CHEMBL375530 | DICHLORORIBOBENZIMIDAZOLE | — | 1 | 4.53 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL14762 | SELICICLIB | IC50 | = | 18460.0 | nM | 4.73 |
| CHEMBL375530 | DICHLORORIBOBENZIMIDAZOLE | IC50 | = | 29520.0 | nM | 4.53 |