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Assay Detail

CHEMBL1250280

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Binding
Inhibition of CDK1
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Cyclin-dependent kinase 1 (CHEMBL308)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Selectivity and potency of cyclin-dependent kinase inhibitors.
Sridhar J, Akula N, Pattabiraman N.
AAPS J (2006) 8 : E204 -E221
PubMed 16584130 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 23 6.86 9.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL194721 1 9.00
CHEMBL102926 1 8.30
CHEMBL291324 1 8.22
CHEMBL1241849 1 7.82
CHEMBL79049 1 7.70
CHEMBL428690 ALVOCIDIB 3.0 1 7.52
CHEMBL50894 ALSTERPAULLONE 1 7.46
CHEMBL1207227 1 7.40
CHEMBL258805 SU-9516 1.0 1 7.26
CHEMBL1241758 1 7.26
CHEMBL1241662 1 6.98
CHEMBL336242 1 6.92
CHEMBL133498 1 6.89
CHEMBL115220 1 6.55
CHEMBL14762 SELICICLIB 2.0 1 6.35
CHEMBL1242973 BUTYROLACTONE I 1 6.22
CHEMBL1234009 1 5.80
CHEMBL141247 1 5.75
CHEMBL1242832 1 5.55
CHEMBL1241661 1 5.54
CHEMBL1241935 1 5.30
CHEMBL280074 OLOMOUCINE 1 5.16
CHEMBL1242367 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL194721 IC50 = 1.0 nM 9.00
CHEMBL102926 IC50 = 5.0 nM 8.30
CHEMBL291324 IC50 = 6.0 nM 8.22
CHEMBL1241849 IC50 = 15.0 nM 7.82
CHEMBL79049 IC50 = 20.0 nM 7.70
CHEMBL428690 ALVOCIDIB IC50 = 30.0 nM 7.52
CHEMBL50894 ALSTERPAULLONE IC50 = 35.0 nM 7.46
CHEMBL1207227 IC50 = 40.0 nM 7.40
CHEMBL258805 SU-9516 IC50 = 55.0 nM 7.26
CHEMBL1241758 IC50 = 55.0 nM 7.26
CHEMBL1241662 IC50 = 104.0 nM 6.98
CHEMBL336242 IC50 = 120.0 nM 6.92
CHEMBL133498 IC50 = 130.0 nM 6.89
CHEMBL115220 IC50 = 279.0 nM 6.55
CHEMBL14762 SELICICLIB IC50 = 450.0 nM 6.35
CHEMBL1242973 BUTYROLACTONE I IC50 = 600.0 nM 6.22
CHEMBL1234009 IC50 = 1600.0 nM 5.80
CHEMBL141247 IC50 = 1800.0 nM 5.75
CHEMBL1242832 IC50 = 2800.0 nM 5.55
CHEMBL1241661 IC50 = 2900.0 nM 5.54
CHEMBL1241935 IC50 = 5000.0 nM 5.30
CHEMBL280074 OLOMOUCINE IC50 = 7000.0 nM 5.16
CHEMBL1242367 IC50 > 50000.0 nM -