Assay Detail
Functional
CHEMBL1250565
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Cytotoxicity against human HT-29 cells after 72 hrs by MTT assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HT-29 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
4-(3-Halo/amino-4,5-dimethoxyphenyl)-5-aryloxazoles and -N-methylimidazoles that are cytotoxic against combretastatin A resistant tumor cells and vascular disrupting in a cisplatin resistant germ cell tumor model.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 7.93 | 10.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1254819 | — | — | 1 | 10.70 |
| CHEMBL1254650 | — | — | 1 | 10.22 |
| CHEMBL1254818 | — | — | 1 | 9.70 |
| CHEMBL1254905 | — | — | 1 | 8.37 |
| CHEMBL1253816 | — | — | 1 | 7.85 |
| CHEMBL1254992 | — | — | 1 | 7.24 |
| CHEMBL46215 | — | — | 1 | 7.19 |
| CHEMBL1254904 | — | — | 1 | 6.29 |
| CHEMBL1253197 | — | — | 1 | 6.28 |
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 5.44 |
| CHEMBL1255078 | — | — | 1 | - |
| CHEMBL1255077 | — | — | 1 | - |
| CHEMBL1254993 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1254819 | — | IC50 | = | 0.02 | nM | 10.70 |
| CHEMBL1254650 | — | IC50 | = | 0.06 | nM | 10.22 |
| CHEMBL1254818 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL1254905 | — | IC50 | = | 4.3 | nM | 8.37 |
| CHEMBL1253816 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL1254992 | — | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL46215 | — | IC50 | = | 64.0 | nM | 7.19 |
| CHEMBL1254904 | — | IC50 | = | 510.0 | nM | 6.29 |
| CHEMBL1253197 | — | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL1255078 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL1255077 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1254993 | — | IC50 | > | 15000.0 | nM | - |