Assay Detail
Binding
CHEMBL1250684
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of His-tagged human VEGFR2 expressed in Sf9 cells
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Sf9 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Vascular endothelial growth factor receptor 2 (CHEMBL279) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
N-phenyl-N'-[4-(5H-pyrrolo[3,2-d]pyrimidin-4-yloxy)phenyl]ureas as novel inhibitors of VEGFR and FGFR kinases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 26 | 7.84 | 8.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1254193 | — | — | 1 | 8.57 |
| CHEMBL1253837 | — | — | 1 | 8.57 |
| CHEMBL1254277 | — | — | 1 | 8.54 |
| CHEMBL1254190 | — | — | 1 | 8.43 |
| CHEMBL1254278 | — | — | 1 | 8.42 |
| CHEMBL1253916 | — | — | 1 | 8.40 |
| CHEMBL1254355 | — | — | 1 | 8.40 |
| CHEMBL1254356 | — | — | 1 | 8.12 |
| CHEMBL1253194 | — | — | 1 | 8.05 |
| CHEMBL1253838 | — | — | 1 | 8.05 |
| CHEMBL1254515 | — | — | 1 | 8.03 |
| CHEMBL1254755 | — | — | 1 | 8.03 |
| CHEMBL1255098 | — | — | 1 | 8.01 |
| CHEMBL1255097 | — | — | 1 | 7.96 |
| CHEMBL1254839 | — | — | 1 | 7.92 |
| CHEMBL1253917 | — | — | 1 | 7.85 |
| CHEMBL1254006 | — | — | 1 | 7.75 |
| CHEMBL1254671 | — | — | 1 | 7.72 |
| CHEMBL1254437 | — | — | 1 | 7.72 |
| CHEMBL1254840 | — | — | 1 | 7.70 |
| CHEMBL1255013 | — | — | 1 | 7.64 |
| CHEMBL1254927 | — | — | 1 | 7.22 |
| CHEMBL1254595 | — | — | 1 | 7.21 |
| CHEMBL1254097 | — | — | 1 | 6.68 |
| CHEMBL1254098 | — | — | 1 | 6.64 |
| CHEMBL1254192 | — | — | 1 | 6.19 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1254193 | — | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL1253837 | — | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL1254277 | — | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL1254190 | — | IC50 | = | 3.7 | nM | 8.43 |
| CHEMBL1254278 | — | IC50 | = | 3.8 | nM | 8.42 |
| CHEMBL1253916 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL1254355 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL1254356 | — | IC50 | = | 7.6 | nM | 8.12 |
| CHEMBL1253194 | — | IC50 | = | 8.9 | nM | 8.05 |
| CHEMBL1253838 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL1254515 | — | IC50 | = | 9.4 | nM | 8.03 |
| CHEMBL1254755 | — | IC50 | = | 9.3 | nM | 8.03 |
| CHEMBL1255098 | — | IC50 | = | 9.7 | nM | 8.01 |
| CHEMBL1255097 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL1254839 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL1253917 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL1254006 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL1254671 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL1254437 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL1254840 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL1255013 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL1254927 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL1254595 | — | IC50 | = | 61.0 | nM | 7.21 |
| CHEMBL1254097 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL1254098 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL1254192 | — | IC50 | = | 650.0 | nM | 6.19 |