Assay Detail
Binding
CHEMBL1250951
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Inhibition of human GST-tagged PLD2A in human HEK293 cells
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis, and biological evaluation of halogenated N-(2-(4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-8-yl)ethyl)benzamides: discovery of an isoform-selective small molecule phospholipase D2 inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 28 | 6.71 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1254577 | — | — | 1 | 7.70 |
| CHEMBL1254736 | — | — | 1 | 7.60 |
| CHEMBL1253900 | — | — | 1 | 7.52 |
| CHEMBL1253820 | — | — | 1 | 7.40 |
| CHEMBL1254081 | — | — | 1 | 7.30 |
| CHEMBL1254495 | — | — | 1 | 7.22 |
| CHEMBL1254653 | — | — | 1 | 7.20 |
| CHEMBL1254823 | — | — | 1 | 7.16 |
| CHEMBL1254996 | — | — | 1 | 7.16 |
| CHEMBL1254908 | — | — | 1 | 7.14 |
| CHEMBL1255082 | — | — | 1 | 7.10 |
| CHEMBL1254176 | — | — | 1 | 7.00 |
| CHEMBL1255081 | — | — | 1 | 7.00 |
| CHEMBL511475 | — | — | 1 | 6.96 |
| CHEMBL1254909 | — | — | 1 | 6.92 |
| CHEMBL471056 | — | — | 1 | 6.85 |
| CHEMBL1254822 | — | — | 1 | 6.78 |
| CHEMBL1253988 | — | — | 1 | 6.70 |
| CHEMBL1254737 | — | — | 1 | 6.54 |
| CHEMBL1254082 | — | — | 1 | 6.46 |
| CHEMBL1254576 | — | — | 1 | 6.44 |
| CHEMBL1253821 | — | — | 1 | 6.21 |
| CHEMBL1254997 | — | — | 1 | 6.18 |
| CHEMBL1253901 | — | — | 1 | 6.18 |
| CHEMBL492572 | — | — | 1 | 5.75 |
| CHEMBL1253989 | — | — | 1 | 5.25 |
| CHEMBL1254654 | — | — | 1 | 5.17 |
| CHEMBL1254175 | — | — | 1 | 5.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1254577 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL1254736 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL1253900 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL1253820 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL1254081 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL1254495 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL1254653 | — | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL1254823 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL1254996 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL1254908 | — | IC50 | = | 73.0 | nM | 7.14 |
| CHEMBL1255082 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL1254176 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL1255081 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL511475 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL1254909 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL471056 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL1254822 | — | IC50 | = | 165.0 | nM | 6.78 |
| CHEMBL1253988 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL1254737 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL1254082 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL1254576 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL1253821 | — | IC50 | = | 610.0 | nM | 6.21 |
| CHEMBL1254997 | — | IC50 | = | 660.0 | nM | 6.18 |
| CHEMBL1253901 | — | IC50 | = | 655.0 | nM | 6.18 |
| CHEMBL492572 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL1253989 | — | IC50 | = | 5670.0 | nM | 5.25 |
| CHEMBL1254654 | — | IC50 | = | 6700.0 | nM | 5.17 |
| CHEMBL1254175 | — | IC50 | = | 8000.0 | nM | 5.10 |