Assay Detail
Binding
CHEMBL1251002
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of GST-tagged Bcl-xl/FITC-conjugated Bim interaction by fluorescence polarisation assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Bcl-xL/Bcl-2-like protein 11 (CHEMBL3883287) ↗| Type | PROTEIN-PROTEIN INTERACTION |
| Organism | Homo sapiens |
Publication
Synthesis and biological activities of new di- and trimeric quinoline derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.40 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL376408 | ABT 737 | 1.0 | 1 | 8.70 |
| CHEMBL1254426 | — | — | 1 | 4.54 |
| CHEMBL1253485 | — | — | 1 | 4.33 |
| CHEMBL1253484 | — | — | 1 | 4.03 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL376408 | ABT 737 | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL1254426 | — | IC50 | = | 29000.0 | nM | 4.54 |
| CHEMBL1253485 | — | IC50 | = | 47000.0 | nM | 4.33 |
| CHEMBL1253484 | — | IC50 | = | 92500.0 | nM | 4.03 |