Assay Detail
Binding
CHEMBL1251068
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Displacement of [3H]prazosin from human adrenergic Alpha-1D expressed in CHO cells
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Structure-activity relationships in 1,4-benzodioxan-related compounds. 10. Novel α1-adrenoreceptor antagonists related to openphendioxan: synthesis, biological evaluation, and α1d computational study.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 15 | 8.80 | 10.17 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL43116 | — | — | 1 | 10.17 |
| CHEMBL1254582 | — | — | 1 | 9.75 |
| CHEMBL1254742 | — | — | 1 | 9.41 |
| CHEMBL1254743 | — | — | 1 | 9.29 |
| CHEMBL25554 | — | — | 1 | 9.29 |
| CHEMBL1254828 | — | — | 1 | 9.13 |
| CHEMBL1254829 | — | — | 1 | 9.04 |
| CHEMBL1254659 | — | — | 1 | 8.92 |
| CHEMBL1254660 | — | — | 1 | 8.56 |
| CHEMBL1254914 | — | — | 1 | 8.43 |
| CHEMBL1254915 | — | — | 1 | 8.40 |
| CHEMBL1255002 | — | — | 1 | 8.15 |
| CHEMBL1255003 | — | — | 1 | 7.85 |
| CHEMBL1255085 | — | — | 1 | 7.82 |
| CHEMBL1255086 | — | — | 1 | 7.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL43116 | — | Ki | = | 0.06761 | nM | 10.17 |
| CHEMBL1254582 | — | Ki | = | 0.1778 | nM | 9.75 |
| CHEMBL1254742 | — | Ki | = | 0.389 | nM | 9.41 |
| CHEMBL1254743 | — | Ki | = | 0.5129 | nM | 9.29 |
| CHEMBL25554 | — | Ki | = | 0.5129 | nM | 9.29 |
| CHEMBL1254828 | — | Ki | = | 0.7413 | nM | 9.13 |
| CHEMBL1254829 | — | Ki | = | 0.912 | nM | 9.04 |
| CHEMBL1254659 | — | Ki | = | 1.202 | nM | 8.92 |
| CHEMBL1254660 | — | Ki | = | 2.754 | nM | 8.56 |
| CHEMBL1254914 | — | Ki | = | 3.715 | nM | 8.43 |
| CHEMBL1254915 | — | Ki | = | 3.981 | nM | 8.40 |
| CHEMBL1255002 | — | Ki | = | 7.079 | nM | 8.15 |
| CHEMBL1255003 | — | Ki | = | 14.13 | nM | 7.85 |
| CHEMBL1255085 | — | Ki | = | 15.14 | nM | 7.82 |
| CHEMBL1255086 | — | Ki | = | 17.78 | nM | 7.75 |