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Assay Detail

CHEMBL1252152

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Binding affinity to human galectin 7 at 4 degC by competitive fluorescence polarization assay
35
Total Activities
35
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Galectin-7 (CHEMBL5008)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

1H-1,2,3-triazol-1-yl thiodigalactoside derivatives as high affinity galectin-3 inhibitors.
Salameh BA, Cumpstey I, Sundin A, Leffler H, Nilsson UJ.
Bioorg Med Chem (2010) 18 : 5367 -5378
PubMed 20538469 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Kd 35 5.10 5.70

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1253726 1 5.70
CHEMBL1253217 1 5.55
CHEMBL1253187 1 5.47
CHEMBL1253745 1 5.33
CHEMBL1253744 1 5.30
CHEMBL1253742 1 5.27
CHEMBL1253923 1 5.10
CHEMBL1253743 1 5.08
CHEMBL1253740 1 4.13
CHEMBL1253741 1 4.08
CHEMBL1253738 1 -
CHEMBL1253739 1 -
CHEMBL1254521 1 -
CHEMBL1254599 1 -
CHEMBL1254600 1 -
CHEMBL1254601 1 -
CHEMBL1254676 1 -
CHEMBL1253737 1 -
CHEMBL1254760 1 -
CHEMBL1254761 1 -
CHEMBL1254520 1 -
CHEMBL1254677 1 -
CHEMBL500137 1 -
CHEMBL1253188 1 -
CHEMBL1253843 1 -
CHEMBL1255018 1 -
CHEMBL442951 1 -
CHEMBL502001 1 -
CHEMBL52011 THIODIGALACTOSIDE 1 -
CHEMBL1254013 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1253726 Kd = 2000.0 nM 5.70
CHEMBL1253217 Kd = 2800.0 nM 5.55
CHEMBL1253187 Kd = 3400.0 nM 5.47
CHEMBL1253745 Kd = 4700.0 nM 5.33
CHEMBL1253744 Kd = 5000.0 nM 5.30
CHEMBL1253742 Kd = 5400.0 nM 5.27
CHEMBL1253923 Kd = 8000.0 nM 5.10
CHEMBL1253743 Kd = 8300.0 nM 5.08
CHEMBL1253740 Kd = 74000.0 nM 4.13
CHEMBL1253741 Kd = 83000.0 nM 4.08
CHEMBL1254599 Kd = 1700000.0 nM -
CHEMBL1254933 Kd = 1500000.0 nM -
CHEMBL1254600 Kd = 2800000.0 nM -
CHEMBL1254601 Kd = 2000000.0 nM -
CHEMBL1254676 Kd > 2000000.0 nM -
CHEMBL1253737 Kd = 2400000.0 nM -
CHEMBL1254760 Kd - -
CHEMBL1254761 Kd = 2000000.0 nM -
CHEMBL1254845 Kd - -
CHEMBL1254846 Kd > 5000000.0 nM -
CHEMBL1254847 Kd - -
CHEMBL1254932 Kd = 1100000.0 nM -
CHEMBL1254521 Kd > 5000000.0 nM -
CHEMBL1253739 Kd = 2500000.0 nM -
CHEMBL1253738 Kd = 2200000.0 nM -
CHEMBL1254520 Kd > 5000000.0 nM -
CHEMBL1254677 Kd = 810000.0 nM -
CHEMBL500137 Kd = 2100000.0 nM -
CHEMBL1253188 Kd = 2700000.0 nM -
CHEMBL1253843 Kd = 130000.0 nM -
CHEMBL1255018 Kd > 5000000.0 nM -
CHEMBL442951 Kd = 4800000.0 nM -
CHEMBL502001 Kd = 5500000.0 nM -
CHEMBL52011 THIODIGALACTOSIDE Kd = 160000.0 nM -
CHEMBL1254013 Kd > 100000.0 nM -