Assay Detail
Binding
CHEMBL1252173
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of myristoylated wild type AKT2 expressed in HEK293T cells by in vitro immunoprecipitation kinase assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | HEK-293T |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
RAC-beta serine/threonine-protein kinase (CHEMBL2431) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Inhibitor hijacking of Akt activation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.52 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL379300 | A-443654 | — | 1 | 7.52 |
| CHEMBL1254114 | — | — | 1 | - |
| CHEMBL1254115 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL379300 | A-443654 | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL1254114 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1254115 | — | IC50 | > | 10000.0 | nM | - |