Assay Detail
Binding
CHEMBL1253092
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Inhibition of thymine synthase
2
Total Activities
2
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Novel approaches for targeting thymidylate synthase to overcome the resistance and toxicity of anticancer drugs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 1 | 8.89 | 8.89 |
| IC50 | 1 | 8.92 | 8.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1253498 | — | — | 1 | 8.92 |
| CHEMBL225072 | PEMETREXED | 4.0 | 1 | 8.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1253498 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL225072 | PEMETREXED | Ki | = | 1.3 | nM | 8.89 |