Assay Detail
Binding
CHEMBL1259258
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Displacement of [3H]8-OH-DPAT from 5-HT1A receptor in pig cortex membranes
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Sus scrofa |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Novel pyridylmethylamines as highly selective 5-HT(1A) superagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 9.06 | 9.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL45305 | BEFIRADOL | 2.0 | 1 | 9.48 |
| CHEMBL1259241 | — | — | 1 | 9.07 |
| CHEMBL1258999 | — | — | 1 | 8.96 |
| CHEMBL1259071 | — | — | 1 | 8.74 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL45305 | BEFIRADOL | Ki | = | 0.33 | nM | 9.48 |
| CHEMBL1259241 | — | Ki | = | 0.86 | nM | 9.07 |
| CHEMBL1258999 | — | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL1259071 | — | Ki | = | 1.8 | nM | 8.74 |