Assay Detail
Functional
CHEMBL1259727
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at mineralocorticoid receptor-LBD in human U2OS cells transfected with Gal4-DBD assessed as increase of transactivation activity after 18 hrs by luciferase reporter gene assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | U2OS |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and biochemical characterization of a series of 17α-perfluoroalkylated estradiols as selective ligands for estrogen receptor α.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 11 | 9.47 | 9.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL273453 | ALDOSTERONE | 2.0 | 1 | 9.47 |
| CHEMBL1258901 | — | — | 1 | - |
| CHEMBL1258783 | — | — | 1 | - |
| CHEMBL1256102 | — | — | 1 | - |
| CHEMBL1257167 | — | — | 1 | - |
| CHEMBL1258902 | — | — | 1 | - |
| CHEMBL1256103 | — | — | 1 | - |
| CHEMBL1257168 | — | — | 1 | - |
| CHEMBL1256104 | — | — | 1 | - |
| CHEMBL1257284 | — | — | 1 | - |
| CHEMBL1256105 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL273453 | ALDOSTERONE | EC50 | = | 0.3381 | nM | 9.47 |
| CHEMBL1258901 | — | EC50 | < | 15848.93 | nM | - |
| CHEMBL1258783 | — | EC50 | < | 15848.93 | nM | - |
| CHEMBL1256102 | — | EC50 | < | 15848.93 | nM | - |
| CHEMBL1257167 | — | EC50 | < | 15848.93 | nM | - |
| CHEMBL1258902 | — | EC50 | < | 15848.93 | nM | - |
| CHEMBL1256103 | — | EC50 | < | 15848.93 | nM | - |
| CHEMBL1257168 | — | EC50 | < | 15848.93 | nM | - |
| CHEMBL1256104 | — | EC50 | < | 15848.93 | nM | - |
| CHEMBL1257284 | — | EC50 | < | 15848.93 | nM | - |
| CHEMBL1256105 | — | EC50 | < | 15848.93 | nM | - |