Assay Detail
Binding
CHEMBL1260095
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of b-Raf V600E mutant
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Serine/threonine-protein kinase B-raf (CHEMBL5145) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis of aminoquinazoline derivatives and their antiproliferative activities against melanoma cell line.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 6.07 | 7.42 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1336 | SORAFENIB | 4.0 | 1 | 7.42 |
| CHEMBL1257719 | — | — | 1 | 4.71 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1336 | SORAFENIB | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL1257719 | — | IC50 | = | 19500.0 | nM | 4.71 |