Assay Detail
Binding
CHEMBL1260104
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Taq polymerase
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Thermus aquaticus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and molecular docking study of novel coumarin derivatives containing 4,5-dihydropyrazole moiety as potential antitumor agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 4.89 | 5.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1258983 | — | — | 1 | 5.40 |
| CHEMBL1258869 | — | — | 1 | 5.22 |
| CHEMBL1257134 | — | — | 1 | 5.00 |
| CHEMBL1258868 | — | — | 1 | 4.78 |
| CHEMBL1258982 | — | — | 1 | 4.68 |
| CHEMBL1258748 | — | — | 1 | 4.23 |
| CHEMBL1210130 | — | — | 1 | - |
| CHEMBL1255903 | — | — | 1 | - |
| CHEMBL1258747 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1258983 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL1258869 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL1257134 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL1258868 | — | IC50 | = | 16800.0 | nM | 4.78 |
| CHEMBL1258982 | — | IC50 | = | 20700.0 | nM | 4.68 |
| CHEMBL1258748 | — | IC50 | = | 58500.0 | nM | 4.23 |
| CHEMBL1210130 | — | IC50 | - | — | - | |
| CHEMBL1255903 | — | IC50 | - | — | - | |
| CHEMBL1258747 | — | IC50 | - | — | - |