Assay Detail
Binding
CHEMBL1260105
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of telomerase in human SGC7901 cells by TRAP assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | SGC-7901 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and molecular docking study of novel coumarin derivatives containing 4,5-dihydropyrazole moiety as potential antitumor agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.20 | 5.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1258983 | — | — | 1 | 5.75 |
| CHEMBL1258869 | — | — | 1 | 5.70 |
| CHEMBL284328 | HOMIDIUM BROMIDE | 2.0 | 1 | 5.60 |
| CHEMBL1257134 | — | — | 1 | 5.40 |
| CHEMBL1258868 | — | — | 1 | 5.19 |
| CHEMBL1258982 | — | — | 1 | 5.02 |
| CHEMBL1258748 | — | — | 1 | 4.54 |
| CHEMBL1258747 | — | — | 1 | 4.43 |
| CHEMBL1210130 | — | — | 1 | - |
| CHEMBL1255903 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1258983 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL1258869 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL284328 | HOMIDIUM BROMIDE | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL1257134 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL1258868 | — | IC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL1258982 | — | IC50 | = | 9600.0 | nM | 5.02 |
| CHEMBL1258748 | — | IC50 | = | 29100.0 | nM | 4.54 |
| CHEMBL1258747 | — | IC50 | = | 36700.0 | nM | 4.43 |
| CHEMBL1210130 | — | IC50 | - | — | - | |
| CHEMBL1255903 | — | IC50 | - | — | - |