Assay Detail
Binding
CHEMBL1260233
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Binding affinity to wild type Plasmodium falciparum DHFR by competitive binding assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Plasmodium falciparum |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Preclinical evaluation of the antifolate QN254, 5-chloro- N'6'-(2,5-dimethoxy-benzyl)-quinazoline-2,4,6-triamine, as an antimalarial drug candidate.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 9.19 | 9.41 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL138060 | — | — | 1 | 9.41 |
| CHEMBL129788 | — | — | 1 | 9.30 |
| CHEMBL36 | PYRIMETHAMINE | 4.0 | 1 | 9.23 |
| CHEMBL747 | CYCLOGUANIL | 2.0 | 1 | 8.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL138060 | — | Ki | = | 0.39 | nM | 9.41 |
| CHEMBL129788 | — | Ki | = | 0.5 | nM | 9.30 |
| CHEMBL36 | PYRIMETHAMINE | Ki | = | 0.59 | nM | 9.23 |
| CHEMBL747 | CYCLOGUANIL | Ki | = | 1.51 | nM | 8.82 |