Assay Detail
Binding
CHEMBL1260396
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Inhibition of [3H]PDBu binding to PKC delta C1A peptide
5
Total Activities
5
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Role of the phenolic hydroxyl group in the biological activities of simplified analogue of aplysiatoxin with antiproliferative activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 6.71 | 7.92 |
| Kd | 1 | 7.29 | 7.29 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1256416 | APLYSIATOXIN | — | 1 | 7.92 |
| CHEMBL27768 | — | — | 1 | 7.29 |
| CHEMBL1258117 | — | — | 1 | 6.89 |
| CHEMBL1258348 | — | — | 1 | 6.85 |
| CHEMBL1258349 | — | — | 1 | 5.17 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1256416 | APLYSIATOXIN | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL27768 | — | Kd | = | 51.9 | nM | 7.29 |
| CHEMBL1258117 | — | Ki | = | 130.0 | nM | 6.89 |
| CHEMBL1258348 | — | Ki | = | 140.0 | nM | 6.85 |
| CHEMBL1258349 | — | Ki | = | 6800.0 | nM | 5.17 |