Assay Detail
Binding
CHEMBL1260397
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Inhibition of [3H]PDBu binding to PKC delta C1B peptide
5
Total Activities
5
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Role of the phenolic hydroxyl group in the biological activities of simplified analogue of aplysiatoxin with antiproliferative activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 8.08 | 9.39 |
| Kd | 1 | 9.28 | 9.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1256416 | APLYSIATOXIN | — | 1 | 9.39 |
| CHEMBL27768 | — | — | 1 | 9.28 |
| CHEMBL1258348 | — | — | 1 | 8.13 |
| CHEMBL1258117 | — | — | 1 | 8.01 |
| CHEMBL1258349 | — | — | 1 | 6.77 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1256416 | APLYSIATOXIN | Ki | = | 0.41 | nM | 9.39 |
| CHEMBL27768 | — | Kd | = | 0.53 | nM | 9.28 |
| CHEMBL1258348 | — | Ki | = | 7.4 | nM | 8.13 |
| CHEMBL1258117 | — | Ki | = | 9.8 | nM | 8.01 |
| CHEMBL1258349 | — | Ki | = | 170.0 | nM | 6.77 |