Assay Detail
Binding
CHEMBL1260557
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]dofetilide from human ERG
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Voltage-gated inwardly rectifying potassium channel KCNH2 (CHEMBL240) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
6-Alkoxyisoindolin-1-one based dopamine D2 partial agonists as potential antipsychotics.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 27 | 5.89 | 6.36 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1258880 | — | — | 1 | 6.36 |
| CHEMBL1112 | ARIPIPRAZOLE | 4.0 | 1 | 6.22 |
| CHEMBL1258312 | — | — | 1 | 6.11 |
| CHEMBL1257145 | — | — | 1 | 6.04 |
| CHEMBL1258426 | — | — | 1 | 6.03 |
| CHEMBL1257144 | — | — | 1 | 6.01 |
| CHEMBL1258761 | — | — | 1 | 5.89 |
| CHEMBL1258425 | — | — | 1 | 5.81 |
| CHEMBL1258532 | — | — | 1 | 5.78 |
| CHEMBL1258647 | — | — | 1 | 5.73 |
| CHEMBL1257261 | — | — | 1 | 5.73 |
| CHEMBL1258879 | — | — | 1 | 5.69 |
| CHEMBL1258533 | — | — | 1 | 5.55 |
| CHEMBL1258648 | — | — | 1 | 5.44 |
| CHEMBL1258760 | — | — | 1 | - |
| CHEMBL1257262 | — | — | 1 | - |
| CHEMBL1257382 | — | — | 1 | - |
| CHEMBL1257383 | — | — | 1 | - |
| CHEMBL1257492 | — | — | 1 | - |
| CHEMBL1257493 | — | — | 1 | - |
| CHEMBL1257613 | — | — | 1 | - |
| CHEMBL1257614 | — | — | 1 | - |
| CHEMBL1257734 | — | — | 1 | - |
| CHEMBL1257735 | — | — | 1 | - |
| CHEMBL1257856 | — | — | 1 | - |
| CHEMBL1257857 | — | — | 1 | - |
| CHEMBL1257968 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1258880 | — | Ki | = | 439.0 | nM | 6.36 |
| CHEMBL1112 | ARIPIPRAZOLE | Ki | = | 598.0 | nM | 6.22 |
| CHEMBL1258312 | — | Ki | = | 779.0 | nM | 6.11 |
| CHEMBL1257145 | — | Ki | = | 907.0 | nM | 6.04 |
| CHEMBL1258426 | — | Ki | = | 931.0 | nM | 6.03 |
| CHEMBL1257144 | — | Ki | = | 969.0 | nM | 6.01 |
| CHEMBL1258761 | — | Ki | = | 1290.0 | nM | 5.89 |
| CHEMBL1258425 | — | Ki | = | 1560.0 | nM | 5.81 |
| CHEMBL1258532 | — | Ki | = | 1680.0 | nM | 5.78 |
| CHEMBL1258647 | — | Ki | = | 1850.0 | nM | 5.73 |
| CHEMBL1257261 | — | Ki | = | 1860.0 | nM | 5.73 |
| CHEMBL1258879 | — | Ki | = | 2060.0 | nM | 5.69 |
| CHEMBL1258533 | — | Ki | = | 2810.0 | nM | 5.55 |
| CHEMBL1258648 | — | Ki | = | 3610.0 | nM | 5.44 |
| CHEMBL1258760 | — | Ki | - | — | - | |
| CHEMBL1257262 | — | Ki | - | — | - | |
| CHEMBL1257382 | — | Ki | - | — | - | |
| CHEMBL1257383 | — | Ki | - | — | - | |
| CHEMBL1257492 | — | Ki | - | — | - | |
| CHEMBL1257493 | — | Ki | - | — | - | |
| CHEMBL1257613 | — | Ki | - | — | - | |
| CHEMBL1257614 | — | Ki | - | — | - | |
| CHEMBL1257734 | — | Ki | - | — | - | |
| CHEMBL1257735 | — | Ki | - | — | - | |
| CHEMBL1257856 | — | Ki | - | — | - | |
| CHEMBL1257857 | — | Ki | - | — | - | |
| CHEMBL1257968 | — | Ki | - | — | - |