Assay Detail
Binding
CHEMBL1260558
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]-Spiperone from human dopamine D2L receptor expressed in CHO cells
62
Total Activities
62
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
6-Alkoxyisoindolin-1-one based dopamine D2 partial agonists as potential antipsychotics.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 62 | 8.14 | 10.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1257382 | — | — | 1 | 10.24 |
| CHEMBL1257262 | — | — | 1 | 9.52 |
| CHEMBL1257735 | — | — | 1 | 9.24 |
| CHEMBL1257493 | — | — | 1 | 9.24 |
| CHEMBL1258087 | — | — | 1 | 9.09 |
| CHEMBL1258534 | — | — | 1 | 9.06 |
| CHEMBL1258881 | — | — | 1 | 9.05 |
| CHEMBL1258649 | — | — | 1 | 8.85 |
| CHEMBL1257614 | — | — | 1 | 8.81 |
| CHEMBL1257736 | — | — | 1 | 8.77 |
| CHEMBL1258763 | — | — | 1 | 8.73 |
| CHEMBL1257492 | — | — | 1 | 8.68 |
| CHEMBL1257971 | — | — | 1 | 8.63 |
| CHEMBL1257859 | — | — | 1 | 8.61 |
| CHEMBL1257613 | — | — | 1 | 8.58 |
| CHEMBL1257616 | — | — | 1 | 8.52 |
| CHEMBL1258879 | — | — | 1 | 8.50 |
| CHEMBL1258086 | — | — | 1 | 8.42 |
| CHEMBL1112 | ARIPIPRAZOLE | 4.0 | 1 | 8.40 |
| CHEMBL1257734 | — | — | 1 | 8.35 |
| CHEMBL1258085 | — | — | 1 | 8.26 |
| CHEMBL1258313 | — | — | 1 | 8.24 |
| CHEMBL1258650 | — | — | 1 | 8.24 |
| CHEMBL1257385 | — | — | 1 | 8.23 |
| CHEMBL1257494 | — | — | 1 | 8.17 |
| CHEMBL1258647 | — | — | 1 | 8.13 |
| CHEMBL1257261 | — | — | 1 | 8.09 |
| CHEMBL1258314 | — | — | 1 | 8.07 |
| CHEMBL1258428 | — | — | 1 | 8.05 |
| CHEMBL1257146 | — | — | 1 | 8.04 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1257382 | — | Ki | = | 0.0575 | nM | 10.24 |
| CHEMBL1257262 | — | Ki | = | 0.302 | nM | 9.52 |
| CHEMBL1257493 | — | Ki | = | 0.575 | nM | 9.24 |
| CHEMBL1257735 | — | Ki | = | 0.576 | nM | 9.24 |
| CHEMBL1258087 | — | Ki | = | 0.812 | nM | 9.09 |
| CHEMBL1258534 | — | Ki | = | 0.877 | nM | 9.06 |
| CHEMBL1258881 | — | Ki | = | 0.891 | nM | 9.05 |
| CHEMBL1258649 | — | Ki | = | 1.41 | nM | 8.85 |
| CHEMBL1257614 | — | Ki | = | 1.54 | nM | 8.81 |
| CHEMBL1257736 | — | Ki | = | 1.7 | nM | 8.77 |
| CHEMBL1258763 | — | Ki | = | 1.86 | nM | 8.73 |
| CHEMBL1257492 | — | Ki | = | 2.08 | nM | 8.68 |
| CHEMBL1257971 | — | Ki | = | 2.34 | nM | 8.63 |
| CHEMBL1257859 | — | Ki | = | 2.46 | nM | 8.61 |
| CHEMBL1257613 | — | Ki | = | 2.63 | nM | 8.58 |
| CHEMBL1257616 | — | Ki | = | 3.03 | nM | 8.52 |
| CHEMBL1258879 | — | Ki | = | 3.18 | nM | 8.50 |
| CHEMBL1258086 | — | Ki | = | 3.81 | nM | 8.42 |
| CHEMBL1112 | ARIPIPRAZOLE | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL1257734 | — | Ki | = | 4.47 | nM | 8.35 |
| CHEMBL1258085 | — | Ki | = | 5.49 | nM | 8.26 |
| CHEMBL1258313 | — | Ki | = | 5.75 | nM | 8.24 |
| CHEMBL1258650 | — | Ki | = | 5.81 | nM | 8.24 |
| CHEMBL1257385 | — | Ki | = | 5.91 | nM | 8.23 |
| CHEMBL1257494 | — | Ki | = | 6.81 | nM | 8.17 |
| CHEMBL1258647 | — | Ki | = | 7.39 | nM | 8.13 |
| CHEMBL1257261 | — | Ki | = | 8.23 | nM | 8.09 |
| CHEMBL1258314 | — | Ki | = | 8.59 | nM | 8.07 |
| CHEMBL1258428 | — | Ki | = | 8.92 | nM | 8.05 |
| CHEMBL1257146 | — | Ki | = | 9.01 | nM | 8.04 |
| CHEMBL1257737 | — | Ki | = | 9.44 | nM | 8.03 |
| CHEMBL1257264 | — | Ki | = | 9.31 | nM | 8.03 |
| CHEMBL1258535 | — | Ki | = | 9.54 | nM | 8.02 |
| CHEMBL1257147 | — | Ki | = | 9.86 | nM | 8.01 |
| CHEMBL1257145 | — | Ki | = | 10.2 | nM | 7.99 |
| CHEMBL1258200 | — | Ki | = | 10.3 | nM | 7.99 |
| CHEMBL1258882 | — | Ki | = | 10.6 | nM | 7.97 |
| CHEMBL1258762 | — | Ki | = | 11.2 | nM | 7.95 |
| CHEMBL1257968 | — | Ki | = | 11.5 | nM | 7.94 |
| CHEMBL1257383 | — | Ki | = | 12.1 | nM | 7.92 |
| CHEMBL1257495 | — | Ki | = | 13.1 | nM | 7.88 |
| CHEMBL1258761 | — | Ki | = | 13.6 | nM | 7.87 |
| CHEMBL1257615 | — | Ki | = | 13.6 | nM | 7.87 |
| CHEMBL1257969 | — | Ki | = | 13.8 | nM | 7.86 |
| CHEMBL1258427 | — | Ki | = | 15.8 | nM | 7.80 |
| CHEMBL1258533 | — | Ki | = | 16.3 | nM | 7.79 |
| CHEMBL1257970 | — | Ki | = | 16.6 | nM | 7.78 |
| CHEMBL1257858 | — | Ki | = | 21.8 | nM | 7.66 |
| CHEMBL1257857 | — | Ki | = | 22.3 | nM | 7.65 |
| CHEMBL1258084 | — | Ki | = | 22.3 | nM | 7.65 |