Assay Detail
Binding
CHEMBL1260799
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Inhibition sorbitol dehydrogenase by spectrophotometric analysis
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
6,7-Dihydroxy-4-phenylcoumarin as inhibitor of aldose reductase 2.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 4.13 | 4.17 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL56337 | EPALRESTAT | 4.0 | 1 | 4.17 |
| CHEMBL325841 | — | — | 1 | 4.15 |
| CHEMBL244743 | ESCULETIN | — | 1 | 4.08 |
| CHEMBL6466 | COUMARIN | 4.0 | 1 | - |
| CHEMBL150372 | 3-HYDROXYCOUMARIN | — | 1 | - |
| CHEMBL301141 | 4-HYDROXYCOUMARINS | — | 1 | - |
| CHEMBL243263 | 6-HYDROXYCOUMARIN | — | 1 | - |
| CHEMBL51628 | UMBELLIFERONE | — | 1 | - |
| CHEMBL49732 | HERNIARIN | — | 1 | - |
| CHEMBL71851 | SCOPOLETIN | — | 1 | - |
| CHEMBL390320 | ISOSCOPOLETIN | — | 1 | - |
| CHEMBL12208 | HYMECROMONE | 2.0 | 1 | - |
| CHEMBL12253 | — | — | 1 | - |
| CHEMBL313244 | 4-METHYLESCULETIN | — | 1 | - |
| CHEMBL1255817 | — | — | 1 | - |
| CHEMBL1255818 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL56337 | EPALRESTAT | IC50 | = | 67700.0 | nM | 4.17 |
| CHEMBL325841 | — | IC50 | = | 70700.0 | nM | 4.15 |
| CHEMBL244743 | ESCULETIN | IC50 | = | 82900.0 | nM | 4.08 |
| CHEMBL6466 | COUMARIN | IC50 | > | 400000.0 | nM | - |
| CHEMBL150372 | 3-HYDROXYCOUMARIN | IC50 | = | 106000.0 | nM | - |
| CHEMBL301141 | 4-HYDROXYCOUMARINS | IC50 | > | 400000.0 | nM | - |
| CHEMBL243263 | 6-HYDROXYCOUMARIN | IC50 | > | 400000.0 | nM | - |
| CHEMBL51628 | UMBELLIFERONE | IC50 | = | 120000.0 | nM | - |
| CHEMBL49732 | HERNIARIN | IC50 | = | 124000.0 | nM | - |
| CHEMBL71851 | SCOPOLETIN | IC50 | = | 137000.0 | nM | - |
| CHEMBL390320 | ISOSCOPOLETIN | IC50 | > | 250000.0 | nM | - |
| CHEMBL12208 | HYMECROMONE | IC50 | = | 153000.0 | nM | - |
| CHEMBL12253 | — | IC50 | = | 163000.0 | nM | - |
| CHEMBL313244 | 4-METHYLESCULETIN | IC50 | = | 212000.0 | nM | - |
| CHEMBL1255817 | — | IC50 | = | 335000.0 | nM | - |
| CHEMBL1255818 | — | IC50 | = | 288000.0 | nM | - |