Assay Detail
Binding
CHEMBL1261589
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Displacement of [3H]prozosin from rat cloned alpha1d receptor
39
Total Activities
39
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Exploring the neuroleptic substituent in octoclothepin: potential ligands for positron emission tomography with subnanomolar affinity for α(1)-adrenoceptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 39 | 8.92 | 10.12 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL303313 | — | — | 1 | 10.12 |
| CHEMBL1259112 | — | — | 1 | 10.08 |
| CHEMBL1259144 | — | — | 1 | 9.85 |
| CHEMBL1259113 | — | — | 1 | 9.82 |
| CHEMBL1259145 | — | — | 1 | 9.77 |
| CHEMBL1259190 | — | — | 1 | 9.68 |
| CHEMBL64875 | — | — | 1 | 9.64 |
| CHEMBL1259042 | — | — | 1 | 9.62 |
| CHEMBL1258988 | — | — | 1 | 9.49 |
| CHEMBL1259158 | — | — | 1 | 9.43 |
| CHEMBL1259006 | — | — | 1 | 9.21 |
| CHEMBL1259189 | — | — | 1 | 9.19 |
| CHEMBL12713 | SERTINDOLE | 4.0 | 1 | 9.18 |
| CHEMBL1259024 | — | — | 1 | 9.18 |
| CHEMBL1259172 | — | — | 1 | 9.16 |
| CHEMBL64249 | CLOROTEPINE | 2.0 | 1 | 9.11 |
| CHEMBL1259188 | — | — | 1 | 9.11 |
| CHEMBL1259231 | — | — | 1 | 9.01 |
| CHEMBL1259174 | — | — | 1 | 9.01 |
| CHEMBL1259023 | — | — | 1 | 9.00 |
| CHEMBL1259216 | — | — | 1 | 9.00 |
| CHEMBL1258987 | — | — | 1 | 8.85 |
| CHEMBL1259173 | — | — | 1 | 8.82 |
| CHEMBL1259232 | — | — | 1 | 8.72 |
| CHEMBL319352 | — | — | 1 | 8.70 |
| CHEMBL1259203 | — | — | 1 | 8.60 |
| CHEMBL1259217 | — | — | 1 | 8.55 |
| CHEMBL1259187 | — | — | 1 | 8.54 |
| CHEMBL1259005 | — | — | 1 | 8.44 |
| CHEMBL1259079 | — | — | 1 | 8.23 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL303313 | — | Ki | = | 0.076 | nM | 10.12 |
| CHEMBL1259112 | — | Ki | = | 0.084 | nM | 10.08 |
| CHEMBL1259144 | — | Ki | = | 0.14 | nM | 9.85 |
| CHEMBL1259113 | — | Ki | = | 0.15 | nM | 9.82 |
| CHEMBL1259145 | — | Ki | = | 0.17 | nM | 9.77 |
| CHEMBL1259190 | — | Ki | = | 0.21 | nM | 9.68 |
| CHEMBL64875 | — | Ki | = | 0.23 | nM | 9.64 |
| CHEMBL1259042 | — | Ki | = | 0.24 | nM | 9.62 |
| CHEMBL1258988 | — | Ki | = | 0.32 | nM | 9.49 |
| CHEMBL1259158 | — | Ki | = | 0.37 | nM | 9.43 |
| CHEMBL1259006 | — | Ki | = | 0.61 | nM | 9.21 |
| CHEMBL1259189 | — | Ki | = | 0.64 | nM | 9.19 |
| CHEMBL12713 | SERTINDOLE | Ki | = | 0.66 | nM | 9.18 |
| CHEMBL1259024 | — | Ki | = | 0.66 | nM | 9.18 |
| CHEMBL1259172 | — | Ki | = | 0.69 | nM | 9.16 |
| CHEMBL64249 | CLOROTEPINE | Ki | = | 0.77 | nM | 9.11 |
| CHEMBL1259188 | — | Ki | = | 0.77 | nM | 9.11 |
| CHEMBL1259231 | — | Ki | = | 0.97 | nM | 9.01 |
| CHEMBL1259174 | — | Ki | = | 0.98 | nM | 9.01 |
| CHEMBL1259023 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL1259216 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL1258987 | — | Ki | = | 1.4 | nM | 8.85 |
| CHEMBL1259173 | — | Ki | = | 1.5 | nM | 8.82 |
| CHEMBL1259232 | — | Ki | = | 1.9 | nM | 8.72 |
| CHEMBL319352 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL1259203 | — | Ki | = | 2.5 | nM | 8.60 |
| CHEMBL1259217 | — | Ki | = | 2.8 | nM | 8.55 |
| CHEMBL1259187 | — | Ki | = | 2.9 | nM | 8.54 |
| CHEMBL1259005 | — | Ki | = | 3.6 | nM | 8.44 |
| CHEMBL1259079 | — | Ki | = | 5.9 | nM | 8.23 |
| CHEMBL1259043 | — | Ki | = | 6.6 | nM | 8.18 |
| CHEMBL328187 | — | Ki | = | 8.6 | nM | 8.07 |
| CHEMBL1259063 | — | Ki | = | 9.4 | nM | 8.03 |
| CHEMBL1259098 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL1259080 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL1259097 | — | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL1259062 | — | Ki | = | 32.0 | nM | 7.50 |
| CHEMBL1259128 | — | Ki | - | — | - | |
| CHEMBL1259129 | — | Ki | - | — | - |