Assay Detail
Binding
CHEMBL1261748
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Binding affinity to human recombinant mineralocorticoid receptor expressed in baculovirus infected Sf9 cells
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Sf9 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of quinolines as selective glucocorticoid receptor agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 8.03 | 8.90 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL196374 | — | — | 1 | 8.90 |
| CHEMBL263091 | — | — | 1 | 8.10 |
| CHEMBL216272 | — | — | 1 | 7.10 |
| CHEMBL384467 | DEXAMETHASONE | 4.0 | 1 | - |
| CHEMBL1257221 | — | — | 1 | - |
| CHEMBL1257222 | — | — | 1 | - |
| CHEMBL1257342 | — | — | 1 | - |
| CHEMBL1257343 | — | — | 1 | - |
| CHEMBL1257453 | — | — | 1 | - |
| CHEMBL1257454 | — | — | 1 | - |
| CHEMBL1257572 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL196374 | — | IC50 | = | 1.259 | nM | 8.90 |
| CHEMBL263091 | — | IC50 | = | 7.943 | nM | 8.10 |
| CHEMBL216272 | — | IC50 | = | 79.43 | nM | 7.10 |
| CHEMBL384467 | DEXAMETHASONE | IC50 | > | 1000.0 | nM | - |
| CHEMBL1257221 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL1257222 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL1257342 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL1257343 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL1257453 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL1257454 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL1257572 | — | IC50 | > | 1000.0 | nM | - |