Assay Detail
Functional
CHEMBL1261992
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Antimalarial activity against chloroquine-resistant Plasmodium falciparum Dd2 infected in O+ human erythrocytes by [3H]hypoxanthine incorporation assay
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Potent antimalarial activity of histone deacetylase inhibitor analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 6.68 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL99 | TRICHOSTATIN | 1.0 | 1 | 8.10 |
| CHEMBL221655 | — | — | 1 | 7.48 |
| CHEMBL220692 | — | — | 1 | 7.41 |
| CHEMBL218097 | — | — | 1 | 7.39 |
| CHEMBL1257111 | — | — | 1 | 7.32 |
| CHEMBL220489 | — | — | 1 | 7.20 |
| CHEMBL221654 | — | — | 1 | 7.15 |
| CHEMBL219883 | — | — | 1 | 6.99 |
| CHEMBL219271 | — | — | 1 | 6.98 |
| CHEMBL103379 | — | — | 1 | 6.90 |
| CHEMBL1256650 | — | — | 1 | 6.89 |
| CHEMBL318384 | — | — | 1 | 6.77 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 6.53 |
| CHEMBL1256649 | — | — | 1 | 6.52 |
| CHEMBL220490 | — | — | 1 | 6.48 |
| CHEMBL1257086 | — | — | 1 | 6.47 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 6.10 |
| CHEMBL27759 | ENTINOSTAT | 3.0 | 1 | 5.11 |
| CHEMBL380797 | SIRTINOL | — | 1 | 5.04 |
| CHEMBL213934 | — | — | 1 | 4.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL99 | TRICHOSTATIN | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL221655 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL220692 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL218097 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL1257111 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL220489 | — | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL221654 | — | IC50 | = | 71.0 | nM | 7.15 |
| CHEMBL219883 | — | IC50 | = | 102.0 | nM | 6.99 |
| CHEMBL219271 | — | IC50 | = | 105.0 | nM | 6.98 |
| CHEMBL103379 | — | IC50 | = | 125.0 | nM | 6.90 |
| CHEMBL1256650 | — | IC50 | = | 128.0 | nM | 6.89 |
| CHEMBL318384 | — | IC50 | = | 169.0 | nM | 6.77 |
| CHEMBL76 | CHLOROQUINE | IC50 | = | 293.0 | nM | 6.53 |
| CHEMBL1256649 | — | IC50 | = | 305.0 | nM | 6.52 |
| CHEMBL220490 | — | IC50 | = | 334.0 | nM | 6.48 |
| CHEMBL1257086 | — | IC50 | = | 339.0 | nM | 6.47 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL27759 | ENTINOSTAT | IC50 | = | 7800.0 | nM | 5.11 |
| CHEMBL380797 | SIRTINOL | IC50 | = | 9100.0 | nM | 5.04 |
| CHEMBL213934 | — | IC50 | = | 19900.0 | nM | 4.70 |