Assay Detail

CHEMBL1263491

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Binding

Inhibition of Klebsiella pneumoniae Beta-Lactamase SHV-55

ChEMBL ↗

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Target

Beta-lactamase SHV-55 (CHEMBL1255144) ↗

Open DB target context

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Beta-lactamase SHV-55 (CHEMBL1255144) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Beta-lactamase SHV-55

CHEMBL1255144

Anchored from Assay target.

Protein identity Beta-lactamase SHV-55

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Klebsiella pneumoniae
Confidence	9 — Direct single protein target
Curated By	Autocuration

Target

Beta-lactamase SHV-55 (CHEMBL1255144) ↗

Type	SINGLE PROTEIN
Organism	Klebsiella pneumoniae

Publication

Biochemical characterization of SHV-55, an extended-spectrum class A beta-lactamase from Klebsiella pneumoniae.

Mendonça N, Manageiro V, Bonnet R, Caniça M.
Antimicrob Agents Chemother (2008) 52 : 1897 -1898
PubMed 18316524 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	7.70	7.70

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL777	CLAVULANIC ACID	4.0	1	7.70

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL777	CLAVULANIC ACID	IC50	=	20.0	nM	7.70