Assay Detail
Functional
CHEMBL1264580
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antimicrobial activity against Toxoplasma gondii RH containing alpha1-tubulin I235L mutation infected in HFF cells by plaque assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Toxoplasma gondii |
| Cell Type | HFF |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Dinitroaniline activity in Toxoplasma gondii expressing wild-type or mutant alpha-tubulin.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 5.69 | 6.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1223066 | DINITRAMINE | — | 1 | 6.50 |
| CHEMBL1256704 | FLUCHLORALIN | — | 1 | 6.00 |
| CHEMBL1256630 | PENDIMETHALIN | — | 1 | 6.00 |
| CHEMBL1256703 | ETHALFLURALIN | — | 1 | 5.85 |
| CHEMBL1256764 | PROFLURALIN | — | 1 | 5.82 |
| CHEMBL295960 | ORYZALIN | — | 1 | 5.80 |
| CHEMBL31970 | TRIFLURALIN | — | 1 | 5.72 |
| CHEMBL1256763 | NITRALIN | — | 1 | 5.68 |
| CHEMBL1256728 | ISOPROPALIN | — | 1 | 5.66 |
| CHEMBL1256629 | AMIPROPHOS METHYL | — | 1 | 5.41 |
| CHEMBL1256668 | BENFLURALIN | — | 1 | 5.34 |
| CHEMBL53153 | — | — | 1 | 5.11 |
| CHEMBL1256669 | BUTRALIN | — | 1 | 5.04 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1223066 | DINITRAMINE | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL1256704 | FLUCHLORALIN | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL1256630 | PENDIMETHALIN | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL1256703 | ETHALFLURALIN | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL1256764 | PROFLURALIN | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL295960 | ORYZALIN | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL31970 | TRIFLURALIN | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL1256763 | NITRALIN | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL1256728 | ISOPROPALIN | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL1256629 | AMIPROPHOS METHYL | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL1256668 | BENFLURALIN | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL53153 | — | IC50 | = | 7700.0 | nM | 5.11 |
| CHEMBL1256669 | BUTRALIN | IC50 | = | 9100.0 | nM | 5.04 |