Assay Detail

CHEMBL1267136

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional

Antiplasmodial activity against Plasmodium falciparum JF6 after 72 hrs by SYBR green assay

ChEMBL ↗

Free Research Context This assay will appear in recent viewed items on this browser. Open the demo workspace to preview project-only review queues.

Research home Demo workspace

Target

Plasmodium falciparum (CHEMBL364) ↗

Open DB target context

Use one target anchor to keep assay intent, target linkage, and tested compound review aligned.

Loading context

Plasmodium falciparum (CHEMBL364) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Plasmodium falciparum

CHEMBL364

Anchored from Assay target.

Protein identity Plasmodium falciparum

Disease frame Disease evidence pending

Open the live target snapshot or evidence card before reviewing assay metadata so target fit and disease framing stay reusable.

Review focus Open DB context pending

Open the live target snapshot before relying on this target frame across surface handoff.

Open target snapshot Open evidence card Search with this context

Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Plasmodium falciparum
Confidence	1 — Organism
Curated By	Autocuration

Target

Plasmodium falciparum (CHEMBL364) ↗

Type	ORGANISM
Organism	Plasmodium falciparum

Publication

Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.

Yuan J, Johnson RL, Huang R, Wichterman J, Jiang H, Hayton K, Fidock DA, Wellems TE, Inglese J, Austin CP, Su XZ.
Nat Chem Biol (2009) 5 : 765 -771
PubMed 19734910 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	2	5.56	6.80

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL1200517	DIHYDROERGOTAMINE MESYLATE	4.0	1	6.80
CHEMBL22	TRIMETHOPRIM	4.0	1	4.32

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL1200517	DIHYDROERGOTAMINE MESYLATE	IC50	=	159.1	nM	6.80
CHEMBL22	TRIMETHOPRIM	IC50	=	48189.0	nM	4.32