Assay Detail
Functional
CHEMBL1267245
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiplasmodial activity against Plasmodium falciparum 3D7 after 72 hrs by SYBR green assay
559
Total Activities
533
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 559 | 5.42 | 10.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2359966 | QUININE SULFATE | 4.0 | 3 | 10.52 |
| CHEMBL397686 | DIPHENYLENEIODONIUM CHLORIDE | — | 2 | 10.22 |
| CHEMBL121663 | DEQUALINIUM CHLORIDE | 4.0 | 2 | 10.15 |
| CHEMBL34259 | METHOTREXATE | 4.0 | 2 | 10.15 |
| CHEMBL1256647 | — | — | 2 | 10.15 |
| CHEMBL1255782 | EMETINE DIHYDROCHLORIDE HYDRATE | — | 2 | 10.05 |
| CHEMBL935 | — | — | 2 | 10.05 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 2 | 10.05 |
| CHEMBL464538 | — | — | 2 | 10.05 |
| CHEMBL263972 | — | — | 2 | 10.05 |
| CHEMBL554190 | QUINACRINE DIHYDROCHLORIDE | — | 2 | 10.00 |
| CHEMBL578741 | — | — | 2 | 9.55 |
| CHEMBL378544 | VINBLASTINE SULFATE | 4.0 | 2 | 9.28 |
| CHEMBL123 | ELLIPTECINE | — | 2 | 9.25 |
| CHEMBL58 | MITOXANTRONE | 4.0 | 2 | 9.23 |
| CHEMBL1203324 | — | — | 2 | 9.23 |
| CHEMBL160 | CYCLOSPORINE | 4.0 | 2 | 9.20 |
| CHEMBL1117 | IDARUBICIN | 4.0 | 2 | 9.15 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 2 | 9.08 |
| CHEMBL1448 | NICLOSAMIDE | 4.0 | 2 | 9.05 |
| CHEMBL1201063 | PROPAFENONE HYDROCHLORIDE | 4.0 | 2 | 9.03 |
| CHEMBL1256686 | CALCIMYCIN | 2.0 | 2 | 9.00 |
| CHEMBL1256654 | — | — | 2 | 8.98 |
| CHEMBL3707183 | QUINIDINE SULFATE | 4.0 | 1 | 7.60 |
| CHEMBL501867 | VINCRISTINE SULFATE | 4.0 | 1 | 7.00 |
| CHEMBL58510 | CHLOROQUINE PHOSPHATE | 4.0 | 1 | 6.90 |
| CHEMBL1256847 | — | — | 1 | 6.80 |
| CHEMBL1480516 | — | — | 1 | 6.60 |
| CHEMBL126077 | INDIRUBIN-3-MONOXIME | — | 1 | 6.50 |
| CHEMBL587714 | 3',4' DICHLOROBENZAMIL | — | 1 | 6.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2359966 | QUININE SULFATE | IC50 | = | 0.03 | nM | 10.52 |
| CHEMBL397686 | DIPHENYLENEIODONIUM CHLORIDE | IC50 | = | 0.06 | nM | 10.22 |
| CHEMBL1256647 | — | IC50 | = | 0.07 | nM | 10.15 |
| CHEMBL34259 | METHOTREXATE | IC50 | = | 0.07 | nM | 10.15 |
| CHEMBL121663 | DEQUALINIUM CHLORIDE | IC50 | = | 0.07 | nM | 10.15 |
| CHEMBL2359966 | QUININE SULFATE | IC50 | = | 0.09 | nM | 10.05 |
| CHEMBL1255782 | EMETINE DIHYDROCHLORIDE HYDRATE | IC50 | = | 0.09 | nM | 10.05 |
| CHEMBL263972 | — | IC50 | = | 0.09 | nM | 10.05 |
| CHEMBL464538 | — | IC50 | = | 0.09 | nM | 10.05 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 0.09 | nM | 10.05 |
| CHEMBL935 | — | IC50 | = | 0.09 | nM | 10.05 |
| CHEMBL554190 | QUINACRINE DIHYDROCHLORIDE | IC50 | = | 0.1 | nM | 10.00 |
| CHEMBL578741 | — | IC50 | = | 0.28 | nM | 9.55 |
| CHEMBL378544 | VINBLASTINE SULFATE | IC50 | = | 0.52 | nM | 9.28 |
| CHEMBL123 | ELLIPTECINE | IC50 | = | 0.56 | nM | 9.25 |
| CHEMBL58 | MITOXANTRONE | IC50 | = | 0.59 | nM | 9.23 |
| CHEMBL1203324 | — | IC50 | = | 0.59 | nM | 9.23 |
| CHEMBL160 | CYCLOSPORINE | IC50 | = | 0.63 | nM | 9.20 |
| CHEMBL1117 | IDARUBICIN | IC50 | = | 0.71 | nM | 9.15 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 0.83 | nM | 9.08 |
| CHEMBL1448 | NICLOSAMIDE | IC50 | = | 0.89 | nM | 9.05 |
| CHEMBL1201063 | PROPAFENONE HYDROCHLORIDE | IC50 | = | 0.93 | nM | 9.03 |
| CHEMBL1256686 | CALCIMYCIN | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL1256654 | — | IC50 | = | 1.05 | nM | 8.98 |
| CHEMBL3707183 | QUINIDINE SULFATE | IC50 | = | 25.12 | nM | 7.60 |
| CHEMBL397686 | DIPHENYLENEIODONIUM CHLORIDE | IC50 | = | 63.1 | nM | 7.20 |
| CHEMBL121663 | DEQUALINIUM CHLORIDE | IC50 | = | 63.1 | nM | 7.20 |
| CHEMBL1256647 | — | IC50 | = | 79.43 | nM | 7.10 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 79.43 | nM | 7.10 |
| CHEMBL34259 | METHOTREXATE | IC50 | = | 79.43 | nM | 7.10 |
| CHEMBL1255782 | EMETINE DIHYDROCHLORIDE HYDRATE | IC50 | = | 79.43 | nM | 7.10 |
| CHEMBL501867 | VINCRISTINE SULFATE | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL464538 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL263972 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL935 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL2359966 | QUININE SULFATE | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL554190 | QUINACRINE DIHYDROCHLORIDE | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL58510 | CHLOROQUINE PHOSPHATE | IC50 | = | 125.89 | nM | 6.90 |
| CHEMBL1256847 | — | IC50 | = | 158.49 | nM | 6.80 |
| CHEMBL1480516 | — | IC50 | = | 251.19 | nM | 6.60 |
| CHEMBL578741 | — | IC50 | = | 251.19 | nM | 6.60 |
| CHEMBL126077 | INDIRUBIN-3-MONOXIME | IC50 | = | 316.23 | nM | 6.50 |
| CHEMBL587714 | 3',4' DICHLOROBENZAMIL | IC50 | = | 316.23 | nM | 6.50 |
| CHEMBL1134 | DECAMETHONIUM BROMIDE | IC50 | = | 398.11 | nM | 6.40 |
| CHEMBL378544 | VINBLASTINE SULFATE | IC50 | = | 398.11 | nM | 6.40 |
| CHEMBL123 | ELLIPTECINE | IC50 | = | 501.19 | nM | 6.30 |
| CHEMBL78150 | TYRPHOSTIN A9 | IC50 | = | 501.19 | nM | 6.30 |
| CHEMBL1256878 | BENZAMIL HYDROCHLORIDE | IC50 | = | 501.19 | nM | 6.30 |
| CHEMBL1203324 | — | IC50 | = | 630.96 | nM | 6.20 |
| CHEMBL1117 | IDARUBICIN | IC50 | = | 630.96 | nM | 6.20 |