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Assay Detail

CHEMBL1267248

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiplasmodial activity against Plasmodium falciparum Dd2 after 72 hrs by SYBR green assay
ChEMBL ↗
365
Total Activities
340
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Plasmodium falciparum
Confidence 1 — Organism
Curated By Autocuration

Target

Plasmodium falciparum (CHEMBL364) ↗
Type ORGANISM
Organism Plasmodium falciparum

Publication

Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.
Yuan J, Johnson RL, Huang R, Wichterman J, Jiang H, Hayton K, Fidock DA, Wellems TE, Inglese J, Austin CP, Su XZ.
Nat Chem Biol (2009) 5 : 765 -771
PubMed 19734910 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 365 5.46 10.05

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL34259 METHOTREXATE 4.0 2 10.05
CHEMBL1255782 EMETINE DIHYDROCHLORIDE HYDRATE — 2 9.89
CHEMBL1256647 — — 2 9.89
CHEMBL428647 PACLITAXEL 4.0 2 9.82
CHEMBL2359966 QUININE SULFATE 4.0 3 9.80
CHEMBL554190 QUINACRINE DIHYDROCHLORIDE — 2 9.72
CHEMBL121663 DEQUALINIUM CHLORIDE 4.0 2 9.25
CHEMBL160 CYCLOSPORINE 4.0 2 9.15
CHEMBL378544 VINBLASTINE SULFATE 4.0 2 9.03
CHEMBL397686 DIPHENYLENEIODONIUM CHLORIDE — 2 9.00
CHEMBL935 — — 2 9.00
CHEMBL578741 — — 2 9.00
CHEMBL58 MITOXANTRONE 4.0 2 9.00
CHEMBL1201063 PROPAFENONE HYDROCHLORIDE 4.0 2 8.98
CHEMBL1256654 — — 2 8.90
CHEMBL65 CAMPTOTHECIN -1.0 2 8.88
CHEMBL123 ELLIPTECINE — 2 8.85
CHEMBL1117 IDARUBICIN 4.0 2 8.85
CHEMBL1256686 CALCIMYCIN 2.0 2 8.85
CHEMBL1448 NICLOSAMIDE 4.0 2 8.83
CHEMBL1203324 — — 2 8.80
CHEMBL464538 — — 2 8.73
CHEMBL263972 — — 2 8.73
CHEMBL501867 VINCRISTINE SULFATE 4.0 1 7.00
CHEMBL3707183 QUINIDINE SULFATE 4.0 1 6.80
CHEMBL1256847 — — 1 6.50
CHEMBL1534525 MIBEFRADIL DIHYDROCHLORIDE 4.0 1 6.00
CHEMBL78150 TYRPHOSTIN A9 — 1 6.00
CHEMBL1200474 DEMECLOCYCLINE HYDROCHLORIDE 4.0 1 6.00
CHEMBL1696 DESIPRAMINE HYDROCHLORIDE 4.0 1 5.90

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL34259 METHOTREXATE IC50 = 0.09 nM 10.05
CHEMBL1255782 EMETINE DIHYDROCHLORIDE HYDRATE IC50 = 0.13 nM 9.89
CHEMBL1256647 — IC50 = 0.13 nM 9.89
CHEMBL428647 PACLITAXEL IC50 = 0.15 nM 9.82
CHEMBL2359966 QUININE SULFATE IC50 = 0.16 nM 9.80
CHEMBL554190 QUINACRINE DIHYDROCHLORIDE IC50 = 0.19 nM 9.72
CHEMBL2359966 QUININE SULFATE IC50 = 0.35 nM 9.46
CHEMBL121663 DEQUALINIUM CHLORIDE IC50 = 0.56 nM 9.25
CHEMBL160 CYCLOSPORINE IC50 = 0.71 nM 9.15
CHEMBL378544 VINBLASTINE SULFATE IC50 = 0.93 nM 9.03
CHEMBL397686 DIPHENYLENEIODONIUM CHLORIDE IC50 = 1.0 nM 9.00
CHEMBL935 — IC50 = 1.0 nM 9.00
CHEMBL578741 — IC50 = 1.0 nM 9.00
CHEMBL58 MITOXANTRONE IC50 = 1.0 nM 9.00
CHEMBL1201063 PROPAFENONE HYDROCHLORIDE IC50 = 1.05 nM 8.98
CHEMBL1256654 — IC50 = 1.26 nM 8.90
CHEMBL65 CAMPTOTHECIN IC50 = 1.32 nM 8.88
CHEMBL123 ELLIPTECINE IC50 = 1.41 nM 8.85
CHEMBL1117 IDARUBICIN IC50 = 1.41 nM 8.85
CHEMBL1256686 CALCIMYCIN IC50 = 1.41 nM 8.85
CHEMBL1448 NICLOSAMIDE IC50 = 1.48 nM 8.83
CHEMBL1203324 — IC50 = 1.58 nM 8.80
CHEMBL464538 — IC50 = 1.86 nM 8.73
CHEMBL263972 — IC50 = 1.86 nM 8.73
CHEMBL34259 METHOTREXATE IC50 = 79.43 nM 7.10
CHEMBL501867 VINCRISTINE SULFATE IC50 = 100.0 nM 7.00
CHEMBL1255782 EMETINE DIHYDROCHLORIDE HYDRATE IC50 = 125.89 nM 6.90
CHEMBL1256647 — IC50 = 125.89 nM 6.90
CHEMBL428647 PACLITAXEL IC50 = 158.49 nM 6.80
CHEMBL3707183 QUINIDINE SULFATE IC50 = 158.49 nM 6.80
CHEMBL554190 QUINACRINE DIHYDROCHLORIDE IC50 = 199.53 nM 6.70
CHEMBL2359966 QUININE SULFATE IC50 = 316.23 nM 6.50
CHEMBL1256847 — IC50 = 316.23 nM 6.50
CHEMBL378544 VINBLASTINE SULFATE IC50 = 398.11 nM 6.40
CHEMBL121663 DEQUALINIUM CHLORIDE IC50 = 501.19 nM 6.30
CHEMBL160 CYCLOSPORINE IC50 = 630.96 nM 6.20
CHEMBL935 — IC50 = 1000.0 nM 6.00
CHEMBL1200474 DEMECLOCYCLINE HYDROCHLORIDE IC50 = 1000.0 nM 6.00
CHEMBL58 MITOXANTRONE IC50 = 1000.0 nM 6.00
CHEMBL1534525 MIBEFRADIL DIHYDROCHLORIDE IC50 = 1000.0 nM 6.00
CHEMBL397686 DIPHENYLENEIODONIUM CHLORIDE IC50 = 1000.0 nM 6.00
CHEMBL78150 TYRPHOSTIN A9 IC50 = 1000.0 nM 6.00
CHEMBL578741 — IC50 = 1000.0 nM 6.00
CHEMBL1201063 PROPAFENONE HYDROCHLORIDE IC50 = 1000.0 nM 6.00
CHEMBL65 CAMPTOTHECIN IC50 = 1258.93 nM 5.90
CHEMBL1201023 ORPHENADRINE HYDROCHLORIDE IC50 = 1258.93 nM 5.90
CHEMBL1256686 CALCIMYCIN IC50 = 1258.93 nM 5.90
CHEMBL1256654 — IC50 = 1258.93 nM 5.90
CHEMBL1117 IDARUBICIN IC50 = 1258.93 nM 5.90
CHEMBL1696 DESIPRAMINE HYDROCHLORIDE IC50 = 1258.93 nM 5.90