Assay Detail
Binding
CHEMBL1267671
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Inhibition of Beta-lactamase OXA-24/40 expressed in Escherichia coli BL21 (DE3) by nitrocefin hydrolysis assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Penicillin sulfone inhibitors of class D beta-lactamases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 5.37 | 6.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1257120 | — | — | 1 | 6.19 |
| CHEMBL1257121 | — | — | 1 | 5.62 |
| CHEMBL777 | CLAVULANIC ACID | 4.0 | 1 | 4.29 |
| CHEMBL404 | TAZOBACTAM | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1257120 | — | Ki | = | 650.0 | nM | 6.19 |
| CHEMBL1257121 | — | Ki | = | 2400.0 | nM | 5.62 |
| CHEMBL777 | CLAVULANIC ACID | Ki | = | 51000.0 | nM | 4.29 |
| CHEMBL404 | TAZOBACTAM | Ki | = | 271000.0 | nM | - |