Assay Detail
Binding
CHEMBL1272633
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [125I]alpha-Bungarotoxin from alpha7 nAchR in rat brain cell membrane
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Cell Type | brain |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Neuronal acetylcholine receptor subunit alpha-7 (CHEMBL4980) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Identification of 9-fluoro substituted (-)-cytisine derivatives as ligands with high affinity for nicotinic receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 6.13 | 6.95 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL599685 | — | — | 1 | 6.95 |
| CHEMBL365956 | — | — | 1 | 6.40 |
| CHEMBL497939 | CYTISINICLINE | 3.0 | 1 | 6.00 |
| CHEMBL1269417 | — | — | 1 | 6.00 |
| CHEMBL1269418 | — | — | 1 | 5.70 |
| CHEMBL1269456 | — | — | 1 | 5.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL599685 | — | Ki | = | 112.0 | nM | 6.95 |
| CHEMBL365956 | — | Ki | = | 401.1 | nM | 6.40 |
| CHEMBL497939 | CYTISINICLINE | Ki | = | 1000.0 | nM | 6.00 |
| CHEMBL1269417 | — | Ki | = | 1000.0 | nM | 6.00 |
| CHEMBL1269418 | — | Ki | = | 2000.0 | nM | 5.70 |
| CHEMBL1269456 | — | Ki | = | 2000.0 | nM | 5.70 |