Assay Detail
Binding
CHEMBL1272702
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of NEK6
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Serine/threonine-protein kinase Nek6 (CHEMBL4309) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
4,5-Dihydro-1H-pyrazolo[4,3-h]quinazolines as potent and selective Polo-like kinase 1 (PLK1) inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.16 | 6.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1793896 | — | — | 1 | 6.47 |
| CHEMBL1271644 | — | — | 1 | 6.22 |
| CHEMBL1272140 | — | — | 1 | 5.78 |
| CHEMBL1793892 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1793896 | — | IC50 | = | 336.0 | nM | 6.47 |
| CHEMBL1271644 | — | IC50 | = | 595.0 | nM | 6.22 |
| CHEMBL1272140 | — | IC50 | = | 1664.0 | nM | 5.78 |
| CHEMBL1793892 | — | IC50 | > | 10000.0 | nM | - |