Assay Detail
Binding
CHEMBL1273067
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Inhibition of bovine eNOS assessed as nitric oxide mediated oxidation of oxyhemoglobin to methemoglobin
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
N-Substituted acetamidines and 2-methylimidazole derivatives as selective inhibitors of neuronal nitric oxide synthase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 4.04 | 4.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1269155 | EFETOZOLE | 2.0 | 1 | 4.10 |
| CHEMBL450583 | — | — | 1 | 4.10 |
| CHEMBL1269154 | — | — | 1 | 4.05 |
| CHEMBL1269156 | — | — | 1 | 4.00 |
| CHEMBL1269105 | — | — | 1 | 4.00 |
| CHEMBL1269103 | — | — | 1 | 4.00 |
| CHEMBL107251 | 1400W | — | 1 | - |
| CHEMBL1269106 | — | — | 1 | - |
| CHEMBL1269104 | — | — | 1 | - |
| CHEMBL448703 | — | — | 1 | - |
| CHEMBL462334 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1269155 | EFETOZOLE | IC50 | = | 80000.0 | nM | 4.10 |
| CHEMBL450583 | — | IC50 | = | 80000.0 | nM | 4.10 |
| CHEMBL1269154 | — | IC50 | = | 90000.0 | nM | 4.05 |
| CHEMBL1269156 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL1269105 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL1269103 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL107251 | 1400W | IC50 | = | 1100000.0 | nM | - |
| CHEMBL1269106 | — | IC50 | = | 400000.0 | nM | - |
| CHEMBL1269104 | — | IC50 | = | 350000.0 | nM | - |
| CHEMBL448703 | — | IC50 | = | 300000.0 | nM | - |
| CHEMBL462334 | — | IC50 | = | 350000.0 | nM | - |